Purinergic signaling in the modulation of redox biology
Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides and nucleosides. Tri- and diphosphonucleotides are released in physiological and pathological circumstances activating purinergic type 2 receptors (P2 receptors): P2X ion channels and P2Y G protein-coupled rec...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Redox Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231721002962 |
| _version_ | 1818935252429570048 |
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| author | Luiz Eduardo Baggio Savio Raíssa Leite-Aguiar Vinícius Santos Alves Robson Coutinho-Silva Angela T.S. Wyse |
| author_facet | Luiz Eduardo Baggio Savio Raíssa Leite-Aguiar Vinícius Santos Alves Robson Coutinho-Silva Angela T.S. Wyse |
| author_sort | Luiz Eduardo Baggio Savio |
| collection | DOAJ |
| description | Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides and nucleosides. Tri- and diphosphonucleotides are released in physiological and pathological circumstances activating purinergic type 2 receptors (P2 receptors): P2X ion channels and P2Y G protein-coupled receptors. The activation of these receptors triggers the production of reactive oxygen and nitrogen species and alters antioxidant defenses, modulating the redox biology of cells. The activation of P2 receptors is controlled by ecto-enzymes named ectonucleotidases, E-NTPDase1/CD39 and ecto-5’-nucleotidase/CD73) being the most relevant. The first enzyme hydrolyzes adenosine triphosphate (ATP) and adenosine diphosphate (ADP) into adenosine monophosphate (AMP), and the second catalyzes the hydrolysis of AMP to adenosine. The activity of these enzymes is diminished by oxidative stress. Adenosine actives P1 G-coupled receptors that, in general, promote the maintenance of redox hemostasis by decreasing reactive oxygen species (ROS) production and increase antioxidant enzymes. Intracellular purine metabolism can also contribute to ROS generation via xanthine oxidase activity, which converts hypoxanthine into xanthine, and finally, uric acid. In this review, we describe the mechanisms of redox biology modulated by purinergic signaling and how this signaling may be affected by disturbances in the redox homeostasis of cells. |
| first_indexed | 2024-12-20T05:17:13Z |
| format | Article |
| id | doaj.art-be13c32089d64408bcb527aea08032c4 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-12-20T05:17:13Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-be13c32089d64408bcb527aea08032c42022-12-21T19:52:07ZengElsevierRedox Biology2213-23172021-11-0147102137Purinergic signaling in the modulation of redox biologyLuiz Eduardo Baggio Savio0Raíssa Leite-Aguiar1Vinícius Santos Alves2Robson Coutinho-Silva3Angela T.S. Wyse4Instituto de Biofísica Carlos Chagas Filho, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, Brazil; Corresponding author. Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Edifício do Centro de Ciências da Saúde, Bloco G. Av. Carlos Chagas Filho, 373. Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941-902, Brazil.Instituto de Biofísica Carlos Chagas Filho, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, BrazilLaboratório de Neuroproteção e Doenças Metabólicas, Departamento de Bioquímica, ICBS, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, BrazilPurinergic signaling is a cell communication pathway mediated by extracellular nucleotides and nucleosides. Tri- and diphosphonucleotides are released in physiological and pathological circumstances activating purinergic type 2 receptors (P2 receptors): P2X ion channels and P2Y G protein-coupled receptors. The activation of these receptors triggers the production of reactive oxygen and nitrogen species and alters antioxidant defenses, modulating the redox biology of cells. The activation of P2 receptors is controlled by ecto-enzymes named ectonucleotidases, E-NTPDase1/CD39 and ecto-5’-nucleotidase/CD73) being the most relevant. The first enzyme hydrolyzes adenosine triphosphate (ATP) and adenosine diphosphate (ADP) into adenosine monophosphate (AMP), and the second catalyzes the hydrolysis of AMP to adenosine. The activity of these enzymes is diminished by oxidative stress. Adenosine actives P1 G-coupled receptors that, in general, promote the maintenance of redox hemostasis by decreasing reactive oxygen species (ROS) production and increase antioxidant enzymes. Intracellular purine metabolism can also contribute to ROS generation via xanthine oxidase activity, which converts hypoxanthine into xanthine, and finally, uric acid. In this review, we describe the mechanisms of redox biology modulated by purinergic signaling and how this signaling may be affected by disturbances in the redox homeostasis of cells.http://www.sciencedirect.com/science/article/pii/S2213231721002962Oxidative stressROSATPP2 receptorsEctonucleotidasesAdenosine |
| spellingShingle | Luiz Eduardo Baggio Savio Raíssa Leite-Aguiar Vinícius Santos Alves Robson Coutinho-Silva Angela T.S. Wyse Purinergic signaling in the modulation of redox biology Redox Biology Oxidative stress ROS ATP P2 receptors Ectonucleotidases Adenosine |
| title | Purinergic signaling in the modulation of redox biology |
| title_full | Purinergic signaling in the modulation of redox biology |
| title_fullStr | Purinergic signaling in the modulation of redox biology |
| title_full_unstemmed | Purinergic signaling in the modulation of redox biology |
| title_short | Purinergic signaling in the modulation of redox biology |
| title_sort | purinergic signaling in the modulation of redox biology |
| topic | Oxidative stress ROS ATP P2 receptors Ectonucleotidases Adenosine |
| url | http://www.sciencedirect.com/science/article/pii/S2213231721002962 |
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