Should we treat pediatric radiologically isolated syndrome? An 18-year follow-up case report
BackgroundRadiologically isolated syndrome (RIS) describes asymptomatic individuals with incidental radiologic abnormalities suggestive of multiple sclerosis (MS). Much of RIS literature is about adult-onset cases. Treatment of RIS is controversial, especially in pediatric age, but early treatment i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1145260/full |
| _version_ | 1797851325602463744 |
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| author | Elena Barbuti Riccardo Nistri Riccardo Nistri Antonio Ianniello Antonio Ianniello Carlo Pozzilli Carlo Pozzilli Serena Ruggieri Serena Ruggieri |
| author_facet | Elena Barbuti Riccardo Nistri Riccardo Nistri Antonio Ianniello Antonio Ianniello Carlo Pozzilli Carlo Pozzilli Serena Ruggieri Serena Ruggieri |
| author_sort | Elena Barbuti |
| collection | DOAJ |
| description | BackgroundRadiologically isolated syndrome (RIS) describes asymptomatic individuals with incidental radiologic abnormalities suggestive of multiple sclerosis (MS). Much of RIS literature is about adult-onset cases. Treatment of RIS is controversial, especially in pediatric age, but early treatment in selected patients might improve long-term outcomes.Case presentationWe report a single RIS patient who followed up for 18 years in our MS center. At first, she was only monitored with follow-up MRIs. Then, as the lesion load increased, she was treated with a first-line disease-modifying treatment (DMT) reaching MRI stability.ConclusionThis report highlights how treatment can be an appropriate choice in pediatric forms of RIS. |
| first_indexed | 2024-04-09T19:14:59Z |
| format | Article |
| id | doaj.art-be13db436f384587af29b26a925479a4 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-09T19:14:59Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-be13db436f384587af29b26a925479a42023-04-06T06:19:24ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-04-011410.3389/fneur.2023.11452601145260Should we treat pediatric radiologically isolated syndrome? An 18-year follow-up case reportElena Barbuti0Riccardo Nistri1Riccardo Nistri2Antonio Ianniello3Antonio Ianniello4Carlo Pozzilli5Carlo Pozzilli6Serena Ruggieri7Serena Ruggieri8MS Center, S'Andrea Hospital, Sapienza University of Rome, Rome, ItalyMS Center, S'Andrea Hospital, Sapienza University of Rome, Rome, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Rome, ItalyMS Center, S'Andrea Hospital, Sapienza University of Rome, Rome, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Rome, ItalyMS Center, S'Andrea Hospital, Sapienza University of Rome, Rome, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Rome, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Rome, ItalyNeuroimmunology Unit, IRCSS Fondazione Santa Lucia, Rome, ItalyBackgroundRadiologically isolated syndrome (RIS) describes asymptomatic individuals with incidental radiologic abnormalities suggestive of multiple sclerosis (MS). Much of RIS literature is about adult-onset cases. Treatment of RIS is controversial, especially in pediatric age, but early treatment in selected patients might improve long-term outcomes.Case presentationWe report a single RIS patient who followed up for 18 years in our MS center. At first, she was only monitored with follow-up MRIs. Then, as the lesion load increased, she was treated with a first-line disease-modifying treatment (DMT) reaching MRI stability.ConclusionThis report highlights how treatment can be an appropriate choice in pediatric forms of RIS.https://www.frontiersin.org/articles/10.3389/fneur.2023.1145260/fullRISpediatric radiologically isolated syndrometreatmentchildrenmultiple sclerosis |
| spellingShingle | Elena Barbuti Riccardo Nistri Riccardo Nistri Antonio Ianniello Antonio Ianniello Carlo Pozzilli Carlo Pozzilli Serena Ruggieri Serena Ruggieri Should we treat pediatric radiologically isolated syndrome? An 18-year follow-up case report Frontiers in Neurology RIS pediatric radiologically isolated syndrome treatment children multiple sclerosis |
| title | Should we treat pediatric radiologically isolated syndrome? An 18-year follow-up case report |
| title_full | Should we treat pediatric radiologically isolated syndrome? An 18-year follow-up case report |
| title_fullStr | Should we treat pediatric radiologically isolated syndrome? An 18-year follow-up case report |
| title_full_unstemmed | Should we treat pediatric radiologically isolated syndrome? An 18-year follow-up case report |
| title_short | Should we treat pediatric radiologically isolated syndrome? An 18-year follow-up case report |
| title_sort | should we treat pediatric radiologically isolated syndrome an 18 year follow up case report |
| topic | RIS pediatric radiologically isolated syndrome treatment children multiple sclerosis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1145260/full |
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