INVOLVEMENT OF PERFORIN/GRANZYME B-DEPENDENT SIGNALING PATHWAY IN CYTOTOXIC ACTIVITY OF DENDRITIC CELLS TOWARDS HUMAN GLIOBLASTOMA CELLS

INVOLVEMENT OF PERFORIN/GRANZYME B-DEPENDENT SIGNALING PATHWAY IN CYTOTOXIC ACTIVITY OF DENDRITIC CELLS TOWARDS HUMAN GLIOBLASTOMA CELLS

Granule-mediated cytotoxicity of effector cells is a universal mechanism of tumor growth inhibition and induction of tumor cell death. The aim of present study was to evaluate expression of lytic molecules in DCs generated in presence of IFNα (IFN-DCs), and to analyze the role of granule-mediate...

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Bibliographic Details
Main Authors:	T. V. Tyrinova, O. Yu. Leplina, S. V. Mishinov, M. A. Tikhonova, A. V. Kalinovskiy, S. V. Chernov, V. V. Stupak, A. A. Ostanin, E. R. Chernykh
Format:	Article
Language:	Russian
Published:	St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2017-08-01
Series:	Медицинская иммунология
Subjects:	dendritic cells interferon-alpha perforin granzyme b cd107a glioblastoma multiforme
Online Access:	https://www.mimmun.ru/mimmun/article/view/1313

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