Formulation and Evaluation of an Antifungal Ointment Containing Zingiber officinale Roscoe (Zingiberaceae) Essential Oil as Active Principle
The increase incidence of fungal infections, the resistance of fungal strains to existing drugs and the toxicity assimilated to long term usage of antifungal drugs as prompted the search of new alternative from natural source. In this study we have evaluated the antifungal properties of the essenti...
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| Format: | Article |
| Language: | English |
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Mulawarman University
2022-06-01
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| Series: | Journal of Tropical Pharmacy and Chemistry |
| Subjects: | |
| Online Access: | https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/404 |
| _version_ | 1827771107667607552 |
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| author | Nelly Tagnin Nkuete Sandra Leila Nnanga Stephanie Tamdem Guetchueng Nga Nnanga Joseph Ngoupayo |
| author_facet | Nelly Tagnin Nkuete Sandra Leila Nnanga Stephanie Tamdem Guetchueng Nga Nnanga Joseph Ngoupayo |
| author_sort | Nelly Tagnin Nkuete |
| collection | DOAJ |
| description |
The increase incidence of fungal infections, the resistance of fungal strains to existing drugs and the toxicity assimilated to long term usage of antifungal drugs as prompted the search of new alternative from natural source. In this study we have evaluated the antifungal properties of the essential oil of the rhizome of Z. officinale, a plant known for its various biological properties and used in food industry as spice. An antifungal ointment with Z. officinale essential oil as active principle was also formulated and its antifungal properties evaluated. GC/MS analysis identified Zingiberene (22.36%), 1.8-cineole (15.54%), geranial (11.91%), camphene (11.09%) and geraniol (8.75%) as the main constituents of Z. officinale essential oil obtained by hydrodistillation. The oil showed a significant antifungal activity against clinical isolate of Candida krusei with MIC 800 ppm by microdilution method. The formulated ointment containing 10 % glycerol, 60 % vaseline, 8 % hydrosol, 20% lanolin and 2% Zingiber officinale essential oil (Formule E1) was found to follow pharmaceutical standards according to European Pharmacopeia and also showed good antifungal properties
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| first_indexed | 2024-03-11T12:49:23Z |
| format | Article |
| id | doaj.art-be15bf4b87cd4412801da0bfc5f7179a |
| institution | Directory Open Access Journal |
| issn | 2087-7099 2407-6090 |
| language | English |
| last_indexed | 2024-03-11T12:49:23Z |
| publishDate | 2022-06-01 |
| publisher | Mulawarman University |
| record_format | Article |
| series | Journal of Tropical Pharmacy and Chemistry |
| spelling | doaj.art-be15bf4b87cd4412801da0bfc5f7179a2023-11-04T05:57:39ZengMulawarman UniversityJournal of Tropical Pharmacy and Chemistry2087-70992407-60902022-06-016110.25026/jtpc.v6i1.404Formulation and Evaluation of an Antifungal Ointment Containing Zingiber officinale Roscoe (Zingiberaceae) Essential Oil as Active PrincipleNelly Tagnin Nkuete0Sandra Leila Nnanga1Stephanie Tamdem Guetchueng2Nga Nnanga3Joseph Ngoupayo4Centre of Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants studies, Ministry of Scientific Research and Innovation, P.O.Box: 130033 Yaounde-CameroonCentre of Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants studies, Ministry of Scientific Research and Innovation, P.O.Box: 130033 Yaounde-CameroonInstitute of medical research and medicinal plants studiesCentre of Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants studies, Ministry of Scientific Research and Innovation, P.O.Box: 130033 Yaounde-CameroonDepartment of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon The increase incidence of fungal infections, the resistance of fungal strains to existing drugs and the toxicity assimilated to long term usage of antifungal drugs as prompted the search of new alternative from natural source. In this study we have evaluated the antifungal properties of the essential oil of the rhizome of Z. officinale, a plant known for its various biological properties and used in food industry as spice. An antifungal ointment with Z. officinale essential oil as active principle was also formulated and its antifungal properties evaluated. GC/MS analysis identified Zingiberene (22.36%), 1.8-cineole (15.54%), geranial (11.91%), camphene (11.09%) and geraniol (8.75%) as the main constituents of Z. officinale essential oil obtained by hydrodistillation. The oil showed a significant antifungal activity against clinical isolate of Candida krusei with MIC 800 ppm by microdilution method. The formulated ointment containing 10 % glycerol, 60 % vaseline, 8 % hydrosol, 20% lanolin and 2% Zingiber officinale essential oil (Formule E1) was found to follow pharmaceutical standards according to European Pharmacopeia and also showed good antifungal properties https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/404Essential oil; Zingiber officinale; antifungal; ointments |
| spellingShingle | Nelly Tagnin Nkuete Sandra Leila Nnanga Stephanie Tamdem Guetchueng Nga Nnanga Joseph Ngoupayo Formulation and Evaluation of an Antifungal Ointment Containing Zingiber officinale Roscoe (Zingiberaceae) Essential Oil as Active Principle Journal of Tropical Pharmacy and Chemistry Essential oil; Zingiber officinale; antifungal; ointments |
| title | Formulation and Evaluation of an Antifungal Ointment Containing Zingiber officinale Roscoe (Zingiberaceae) Essential Oil as Active Principle |
| title_full | Formulation and Evaluation of an Antifungal Ointment Containing Zingiber officinale Roscoe (Zingiberaceae) Essential Oil as Active Principle |
| title_fullStr | Formulation and Evaluation of an Antifungal Ointment Containing Zingiber officinale Roscoe (Zingiberaceae) Essential Oil as Active Principle |
| title_full_unstemmed | Formulation and Evaluation of an Antifungal Ointment Containing Zingiber officinale Roscoe (Zingiberaceae) Essential Oil as Active Principle |
| title_short | Formulation and Evaluation of an Antifungal Ointment Containing Zingiber officinale Roscoe (Zingiberaceae) Essential Oil as Active Principle |
| title_sort | formulation and evaluation of an antifungal ointment containing zingiber officinale roscoe zingiberaceae essential oil as active principle |
| topic | Essential oil; Zingiber officinale; antifungal; ointments |
| url | https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/404 |
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