Impact of coexposure to aluminum and ethanol on phosphoesterases and transaminases of rat cerebrum
Ubiquitous presence along with uncontrolled use of aluminum and increasing trends of ethanol consumption in India increased the chance of coexposure to aluminum and ethanol. Possibilities are there, that both of them follow common mechanisms to produce neurotoxicity. The phosphomonoesterases and glu...
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2011-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2011/1452-82581101025N.pdf |
| _version_ | 1818522176758743040 |
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| author | Nayak Prasunpriya Sharma Bhusan Shiv Venkata Nadella Chowdary Subbaraya |
| author_facet | Nayak Prasunpriya Sharma Bhusan Shiv Venkata Nadella Chowdary Subbaraya |
| author_sort | Nayak Prasunpriya |
| collection | DOAJ |
| description | Ubiquitous presence along with uncontrolled use of aluminum and increasing trends of ethanol consumption in India increased the chance of coexposure to aluminum and ethanol. Possibilities are there, that both of them follow common mechanisms to produce neurotoxicity. The phosphomonoesterases and glutamate transaminases are studied in rat brain cerebrum after combined exposure to aluminum and varied doses of ethanol for 4 weeks. Dose dependent decreases in growth have been observed. The impact of aluminum on cerebral acidic and alkaline phosphomonoesterases activities were shown to be altered in a dose dependent fashion by the coexposure to ethanol. Aspartate aminotransferase and alanine aminotransferase of the cerebrum were responding differentially to aluminum exposure in the presence of different doses of ethanol exposure. It has been suggested that the ethanolinduced augmentation of impacts of aluminum on the cerebrum is dose dependent and there might be a critical level of ethanol exposure for the observed effect on cerebrum. . |
| first_indexed | 2024-12-11T05:29:51Z |
| format | Article |
| id | doaj.art-be19714838e340a7b38f933d40d539f6 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-12-11T05:29:51Z |
| publishDate | 2011-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-be19714838e340a7b38f933d40d539f62022-12-22T01:19:28ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662011-01-0130125321452-82581101025NImpact of coexposure to aluminum and ethanol on phosphoesterases and transaminases of rat cerebrumNayak Prasunpriya0Sharma Bhusan Shiv1Venkata Nadella2Chowdary Subbaraya3Department of Physiology, NRI Medical College & General Hospital, Chinna Kakani, Mangalagiri (Md), Guntur (Dt), IndiaDepartment of Physiology, Chettinad Hospital & Research Institute, Kelambakkam, IndiaDepartment of Biochemistry, NRI Medical College & General Hospital, Chinna Kakani, Mangalagiri (Md), Guntur (Dt), IndiaDepartment of Physiology, NRI Medical College & General Hospital, Chinna Kakani, Mangalagiri (Md), Guntur (Dt), IndiaUbiquitous presence along with uncontrolled use of aluminum and increasing trends of ethanol consumption in India increased the chance of coexposure to aluminum and ethanol. Possibilities are there, that both of them follow common mechanisms to produce neurotoxicity. The phosphomonoesterases and glutamate transaminases are studied in rat brain cerebrum after combined exposure to aluminum and varied doses of ethanol for 4 weeks. Dose dependent decreases in growth have been observed. The impact of aluminum on cerebral acidic and alkaline phosphomonoesterases activities were shown to be altered in a dose dependent fashion by the coexposure to ethanol. Aspartate aminotransferase and alanine aminotransferase of the cerebrum were responding differentially to aluminum exposure in the presence of different doses of ethanol exposure. It has been suggested that the ethanolinduced augmentation of impacts of aluminum on the cerebrum is dose dependent and there might be a critical level of ethanol exposure for the observed effect on cerebrum. .https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2011/1452-82581101025N.pdfaluminumethanolcerebrumphosphomonoesterasetransaminase |
| spellingShingle | Nayak Prasunpriya Sharma Bhusan Shiv Venkata Nadella Chowdary Subbaraya Impact of coexposure to aluminum and ethanol on phosphoesterases and transaminases of rat cerebrum Journal of Medical Biochemistry aluminum ethanol cerebrum phosphomonoesterase transaminase |
| title | Impact of coexposure to aluminum and ethanol on phosphoesterases and transaminases of rat cerebrum |
| title_full | Impact of coexposure to aluminum and ethanol on phosphoesterases and transaminases of rat cerebrum |
| title_fullStr | Impact of coexposure to aluminum and ethanol on phosphoesterases and transaminases of rat cerebrum |
| title_full_unstemmed | Impact of coexposure to aluminum and ethanol on phosphoesterases and transaminases of rat cerebrum |
| title_short | Impact of coexposure to aluminum and ethanol on phosphoesterases and transaminases of rat cerebrum |
| title_sort | impact of coexposure to aluminum and ethanol on phosphoesterases and transaminases of rat cerebrum |
| topic | aluminum ethanol cerebrum phosphomonoesterase transaminase |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2011/1452-82581101025N.pdf |
| work_keys_str_mv | AT nayakprasunpriya impactofcoexposuretoaluminumandethanolonphosphoesterasesandtransaminasesofratcerebrum AT sharmabhusanshiv impactofcoexposuretoaluminumandethanolonphosphoesterasesandtransaminasesofratcerebrum AT venkatanadella impactofcoexposuretoaluminumandethanolonphosphoesterasesandtransaminasesofratcerebrum AT chowdarysubbaraya impactofcoexposuretoaluminumandethanolonphosphoesterasesandtransaminasesofratcerebrum |