ProTECT—Prediction of T-Cell Epitopes for Cancer Therapy

ProTECT—Prediction of T-Cell Epitopes for Cancer Therapy

Somatic mutations in cancers affecting protein coding genes can give rise to potentially therapeutic neoepitopes. These neoepitopes can guide Adoptive Cell Therapies and Peptide- and RNA-based Neoepitope Vaccines to selectively target tumor cells using autologous patient cytotoxic T-cells. Currently...

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Bibliographic Details
Main Authors: Arjun A. Rao, Ada A. Madejska, Jacob Pfeil, Benedict Paten, Sofie R. Salama, David Haussler
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
cancer
neoepitope
neoantigen
automated prediction
vaccine
cancer immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.483296/full

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