Involvement of the inhibition of mitochondrial apoptotic, p53, NF-κB pathways and the activation of Nrf2/HO-1 pathway in the protective effects of curcumin against copper sulfate-induced nephrotoxicity in mice

Involvement of the inhibition of mitochondrial apoptotic, p53, NF-κB pathways and the activation of Nrf2/HO-1 pathway in the protective effects of curcumin against copper sulfate-induced nephrotoxicity in mice

Chronic copper exposure could cause potential nephrotoxicity and effective therapy strategies are limited. This study investigated the protective effects of curcumin on copper sulfate (CuSO4)-induced renal damage in a mouse model and the underlying molecular mechanisms. Mice were administrated orall...

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Bibliographic Details
Main Authors: Chongshan Dai, Meng Li, Yue Liu, Diem Hong Tran, Haiyang Jiang, Shusheng Tang, Jianzhong Shen
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Copper
Oxidative stress
Curcumin
Nephrotoxicity
Nrf2/HO-1 pathway
NF-κB pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322013203

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