Revised National Tuberculosis Control Program regimens with and without directly observed treatment, short-course: A comparative study of therapeutic cure rate and adverse reactions
Objective: To compare the therapeutic cure rate and adverse reactions in the regimens of the Revised National Tuberculosis Control Program (RNTCP) with directly observed treatment, short-course (DOTS) and without DOTS. Materials and Methods: Fifty patients in the DOTS regimen and 50 patients in the...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Perspectives in Clinical Research |
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| Online Access: | http://www.picronline.org/article.asp?issn=2229-3485;year=2014;volume=5;issue=1;spage=16;epage=19;aulast=Sivaraj |
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| author | Rengaraj Sivaraj Sivaraj Umarani Subramani Parasuraman Pyapti Muralidhar |
| author_facet | Rengaraj Sivaraj Sivaraj Umarani Subramani Parasuraman Pyapti Muralidhar |
| author_sort | Rengaraj Sivaraj |
| collection | DOAJ |
| description | Objective: To compare the therapeutic cure rate and adverse reactions in the regimens of the Revised National Tuberculosis Control Program (RNTCP) with directly observed treatment, short-course (DOTS) and without DOTS. Materials and Methods: Fifty patients in the DOTS regimen and 50 patients in the non-DOTS regimen were enrolled in the study. All the participants were asked to come regularly for 3 consecutive days for sputum collection, and the sputum samples were examined for acid-fast bacilli. If tuberculosis (TB) was confirmed, the disease status was confirmed through a chest X-ray (PA view). The participants were monitored for adverse events arising from the use of anti-TB drugs for the next 6 months. Results: The TB cure rates for RNTCP with DOTS and RNTCP with non-DOTS were 80% and 66%, respectively. The DOTS therapy had a better cure rate for radiologically positive, sputum-positive cases compared with the non-DOTS regimen group. The non-DOTS treatment regimen had significantly increased numbers of adverse events in the hepatic and hematinic systems. Conclusion: The DOTS regimen has higher cure rates and a lower incidence of adverse reactions compared with the non-DOTS regimen. |
| first_indexed | 2024-12-13T01:59:25Z |
| format | Article |
| id | doaj.art-be1d08d994b2493fa04901448f87e9df |
| institution | Directory Open Access Journal |
| issn | 2229-3485 |
| language | English |
| last_indexed | 2024-12-13T01:59:25Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Perspectives in Clinical Research |
| spelling | doaj.art-be1d08d994b2493fa04901448f87e9df2022-12-22T00:03:18ZengWolters Kluwer Medknow PublicationsPerspectives in Clinical Research2229-34852014-01-0151161910.4103/2229-3485.124557Revised National Tuberculosis Control Program regimens with and without directly observed treatment, short-course: A comparative study of therapeutic cure rate and adverse reactionsRengaraj SivarajSivaraj UmaraniSubramani ParasuramanPyapti MuralidharObjective: To compare the therapeutic cure rate and adverse reactions in the regimens of the Revised National Tuberculosis Control Program (RNTCP) with directly observed treatment, short-course (DOTS) and without DOTS. Materials and Methods: Fifty patients in the DOTS regimen and 50 patients in the non-DOTS regimen were enrolled in the study. All the participants were asked to come regularly for 3 consecutive days for sputum collection, and the sputum samples were examined for acid-fast bacilli. If tuberculosis (TB) was confirmed, the disease status was confirmed through a chest X-ray (PA view). The participants were monitored for adverse events arising from the use of anti-TB drugs for the next 6 months. Results: The TB cure rates for RNTCP with DOTS and RNTCP with non-DOTS were 80% and 66%, respectively. The DOTS therapy had a better cure rate for radiologically positive, sputum-positive cases compared with the non-DOTS regimen group. The non-DOTS treatment regimen had significantly increased numbers of adverse events in the hepatic and hematinic systems. Conclusion: The DOTS regimen has higher cure rates and a lower incidence of adverse reactions compared with the non-DOTS regimen.http://www.picronline.org/article.asp?issn=2229-3485;year=2014;volume=5;issue=1;spage=16;epage=19;aulast=SivarajAdverse drug reactiondirectly observed treatmentshort-courseRevised National Tuberculosis Control Programtuberculosis |
| spellingShingle | Rengaraj Sivaraj Sivaraj Umarani Subramani Parasuraman Pyapti Muralidhar Revised National Tuberculosis Control Program regimens with and without directly observed treatment, short-course: A comparative study of therapeutic cure rate and adverse reactions Perspectives in Clinical Research Adverse drug reaction directly observed treatment short-course Revised National Tuberculosis Control Program tuberculosis |
| title | Revised National Tuberculosis Control Program regimens with and without directly observed treatment, short-course: A comparative study of therapeutic cure rate and adverse reactions |
| title_full | Revised National Tuberculosis Control Program regimens with and without directly observed treatment, short-course: A comparative study of therapeutic cure rate and adverse reactions |
| title_fullStr | Revised National Tuberculosis Control Program regimens with and without directly observed treatment, short-course: A comparative study of therapeutic cure rate and adverse reactions |
| title_full_unstemmed | Revised National Tuberculosis Control Program regimens with and without directly observed treatment, short-course: A comparative study of therapeutic cure rate and adverse reactions |
| title_short | Revised National Tuberculosis Control Program regimens with and without directly observed treatment, short-course: A comparative study of therapeutic cure rate and adverse reactions |
| title_sort | revised national tuberculosis control program regimens with and without directly observed treatment short course a comparative study of therapeutic cure rate and adverse reactions |
| topic | Adverse drug reaction directly observed treatment short-course Revised National Tuberculosis Control Program tuberculosis |
| url | http://www.picronline.org/article.asp?issn=2229-3485;year=2014;volume=5;issue=1;spage=16;epage=19;aulast=Sivaraj |
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