Pneumonia caused by toxic epidermal necrolysis
Abstract A well‐functioning 68 year old gentleman presented to our hospital with a macular rash 2 weeks after starting a course of Ciprofloxacin. There was rapid progression of skin involvement including the mucosa, complicated by pancytopaenia. Toxic Epidermal Necrolysis (TEN) was suspected and the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-11-01
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| Series: | Respirology Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rcr2.1046 |
| _version_ | 1797985893893537792 |
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| author | Dominic Doyle Amy Long Desmond M. Murphy |
| author_facet | Dominic Doyle Amy Long Desmond M. Murphy |
| author_sort | Dominic Doyle |
| collection | DOAJ |
| description | Abstract A well‐functioning 68 year old gentleman presented to our hospital with a macular rash 2 weeks after starting a course of Ciprofloxacin. There was rapid progression of skin involvement including the mucosa, complicated by pancytopaenia. Toxic Epidermal Necrolysis (TEN) was suspected and the patient was administered intravenous immunoglobulins and granulocyte colony stimulating factor. TEN was confirmed on skin biopsy and a lymphocyte transformation test demonstrated sensitisation to Ciprofloxacin. The patient developed multifocal pulmonary infiltrates with evidence of pulmonary involvement and probable pneumonia after 1 week and was treated with broad spectrum antibiotics. He also became dysphagic and suffered recurrent aspiration pneumonias. Follow up studies revealed fixed airways obstruction and features of bronchiolitis on computed tomography. This case highlights pulmonary involvement which can become a chronic complication of TEN, itself precipitated by the rare drug cause of Ciprofloxacin. |
| first_indexed | 2024-04-11T07:24:45Z |
| format | Article |
| id | doaj.art-be1faa255d8345a1a99b2438219942b1 |
| institution | Directory Open Access Journal |
| issn | 2051-3380 |
| language | English |
| last_indexed | 2024-04-11T07:24:45Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj.art-be1faa255d8345a1a99b2438219942b12022-12-22T04:37:06ZengWileyRespirology Case Reports2051-33802022-11-011011n/an/a10.1002/rcr2.1046Pneumonia caused by toxic epidermal necrolysisDominic Doyle0Amy Long1Desmond M. Murphy2The Department of Respiratory Medicine Cork University Hospital Cork IrelandThe Department of Respiratory Medicine Cork University Hospital Cork IrelandThe Department of Respiratory Medicine Cork University Hospital Cork IrelandAbstract A well‐functioning 68 year old gentleman presented to our hospital with a macular rash 2 weeks after starting a course of Ciprofloxacin. There was rapid progression of skin involvement including the mucosa, complicated by pancytopaenia. Toxic Epidermal Necrolysis (TEN) was suspected and the patient was administered intravenous immunoglobulins and granulocyte colony stimulating factor. TEN was confirmed on skin biopsy and a lymphocyte transformation test demonstrated sensitisation to Ciprofloxacin. The patient developed multifocal pulmonary infiltrates with evidence of pulmonary involvement and probable pneumonia after 1 week and was treated with broad spectrum antibiotics. He also became dysphagic and suffered recurrent aspiration pneumonias. Follow up studies revealed fixed airways obstruction and features of bronchiolitis on computed tomography. This case highlights pulmonary involvement which can become a chronic complication of TEN, itself precipitated by the rare drug cause of Ciprofloxacin.https://doi.org/10.1002/rcr2.1046ciprofloxacinpneumoniatoxic epidermal necrolysis |
| spellingShingle | Dominic Doyle Amy Long Desmond M. Murphy Pneumonia caused by toxic epidermal necrolysis Respirology Case Reports ciprofloxacin pneumonia toxic epidermal necrolysis |
| title | Pneumonia caused by toxic epidermal necrolysis |
| title_full | Pneumonia caused by toxic epidermal necrolysis |
| title_fullStr | Pneumonia caused by toxic epidermal necrolysis |
| title_full_unstemmed | Pneumonia caused by toxic epidermal necrolysis |
| title_short | Pneumonia caused by toxic epidermal necrolysis |
| title_sort | pneumonia caused by toxic epidermal necrolysis |
| topic | ciprofloxacin pneumonia toxic epidermal necrolysis |
| url | https://doi.org/10.1002/rcr2.1046 |
| work_keys_str_mv | AT dominicdoyle pneumoniacausedbytoxicepidermalnecrolysis AT amylong pneumoniacausedbytoxicepidermalnecrolysis AT desmondmmurphy pneumoniacausedbytoxicepidermalnecrolysis |