Hepatocyte-derived GDF15 suppresses feeding and improves insulin sensitivity in obese mice

Hepatocyte-derived GDF15 suppresses feeding and improves insulin sensitivity in obese mice

Summary: Growth differentiation factor 15 (GDF15) is a stress-induced secreted protein whose circulating levels are increased in the context of obesity. Recombinant GDF15 reduces body weight and improves glycemia in obese models, which is largely attributed to the central action of GDF15 to suppress...

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Bibliographic Details
Main Authors: Bingxian Xie, Anjana Murali, Amber M. Vandevender, Jeffrey Chen, Agustin Gil Silva, Fiona M. Bello, Byron Chuan, Harinath Bahudhanapati, Ian Sipula, Nikolaos Dedousis, Faraaz A. Shah, Christopher P. O’Donnell, Jonathan K. Alder, Michael J. Jurczak
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:iScience
Subjects:
Cellular physiology
Molecular genetics
Diabetology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222018417

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