Visualization of clonal expansion after massive depletion of cells carrying the bovine leukemia virus (BLV) integration sites during the course of disease progression in a BLV naturally-infected cow: a case report

Visualization of clonal expansion after massive depletion of cells carrying the bovine leukemia virus (BLV) integration sites during the course of disease progression in a BLV naturally-infected cow: a case report

Abstract Bovine leukemia virus (BLV) infects cattle, integrates into host DNA as a provirus, and induces malignant B-cell lymphoma. Previous studies have addressed the impact of proviral integration of BLV on BLV-induced leukemogenesis. However, no studies have monitored sequential changes in integr...

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Bibliographic Details
Main Authors: Susumu Saito, Kazuyoshi Hosomichi, Meripet Polat Yamanaka, Tetsuya Mizutani, Shin-nosuke Takeshima, Yoko Aida
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Retrovirology
Subjects:
Bovine leukemia virus
Integration
Provirus
Target enrichment high throughput sequencing system
Massive depletion
Clonal expansion
Online Access:https://doi.org/10.1186/s12977-022-00609-0

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