Methicillin-resistant <i>Staphylococcus aureus</i> nosocomial infection trends in Hospital Universiti Sains Malaysia during 2002-2007
<b>Background and Objectives:</b> Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is a major nosocomial pathogen that causes severe morbidity and mortality in many hospitals worldwide. The aim of the present study was to assess the burden of MRSA nosocomial infectio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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King Faisal Specialist Hospital and Research Centre
2010-01-01
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| Series: | Annals of Saudi Medicine |
| Online Access: | http://www.saudiannals.net/article.asp?issn=0256-4947;year=2010;volume=30;issue=5;spage=358;epage=363;aulast=Al-Talib |
| _version_ | 1819135334241271808 |
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| author | Al-Talib Hassanain Yean Chan Al-Jashamy Karim Hasan Habsah |
| author_facet | Al-Talib Hassanain Yean Chan Al-Jashamy Karim Hasan Habsah |
| author_sort | Al-Talib Hassanain |
| collection | DOAJ |
| description | <b>Background and Objectives:</b> Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is a major nosocomial pathogen that causes severe morbidity and mortality in many hospitals worldwide. The aim of the present study was to assess the burden of MRSA nosocomial infection, its association with factors of interest, and its antimicrobial susceptibility. <b>Methods:</b> This was a retrospective analysis of a database of all <i>S aureus</i> that were cultured from patients admitted to the different wards of Hospital Universiti Sains Malaysia (HUSM) over a period of 6 years. <b>Results:</b> The MRSA infections rate was 10.0 per 1000 hospital admissions. The incidence density rate of MRSA infections during the study period was 1.8 per 1000 patient-days, with annual rates ranging from 0.95 to 3.47 per 1000 patient-days. Duration of hospitalization, previous antibiotic use, and bedside invasive procedures were significantly higher among MRSA than methicillin-sensitive <i>S aureus</i> patients (<i>P</i>>.05). The highest number of MRSA infections were found in orthopedic wards (25.3%), followed by surgical wards (18.2%) and intensive care units (ICUs) (16.4%). All MRSA isolates were resistant to erythromycin (98.0%), co-trimoxazole (94.0%) and gentamicin (92.0%). Clindamycin was the best antibiotic with only 6% resistance. All MRSA isolates were sensitive to vancomycin. <b>Conclusion:</b> The rate of nosocomial MRSA infection per 1000 admissions was higher than that in other studies. The three factors associated most significantly with acquired MRSA infections included duration of hospitalization, antibiotic use, and bedside invasive procedures. This study confirmed that vancomycin-resistant <i>S aureus</i> has not yet been established in HUSM. |
| first_indexed | 2024-12-22T10:17:26Z |
| format | Article |
| id | doaj.art-be228b5ec5e346bb87720866da425465 |
| institution | Directory Open Access Journal |
| issn | 0256-4947 0975-4466 |
| language | English |
| last_indexed | 2024-12-22T10:17:26Z |
| publishDate | 2010-01-01 |
| publisher | King Faisal Specialist Hospital and Research Centre |
| record_format | Article |
| series | Annals of Saudi Medicine |
| spelling | doaj.art-be228b5ec5e346bb87720866da4254652022-12-21T18:29:43ZengKing Faisal Specialist Hospital and Research CentreAnnals of Saudi Medicine0256-49470975-44662010-01-01305358363Methicillin-resistant <i>Staphylococcus aureus</i> nosocomial infection trends in Hospital Universiti Sains Malaysia during 2002-2007Al-Talib HassanainYean ChanAl-Jashamy KarimHasan Habsah<b>Background and Objectives:</b> Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is a major nosocomial pathogen that causes severe morbidity and mortality in many hospitals worldwide. The aim of the present study was to assess the burden of MRSA nosocomial infection, its association with factors of interest, and its antimicrobial susceptibility. <b>Methods:</b> This was a retrospective analysis of a database of all <i>S aureus</i> that were cultured from patients admitted to the different wards of Hospital Universiti Sains Malaysia (HUSM) over a period of 6 years. <b>Results:</b> The MRSA infections rate was 10.0 per 1000 hospital admissions. The incidence density rate of MRSA infections during the study period was 1.8 per 1000 patient-days, with annual rates ranging from 0.95 to 3.47 per 1000 patient-days. Duration of hospitalization, previous antibiotic use, and bedside invasive procedures were significantly higher among MRSA than methicillin-sensitive <i>S aureus</i> patients (<i>P</i>>.05). The highest number of MRSA infections were found in orthopedic wards (25.3%), followed by surgical wards (18.2%) and intensive care units (ICUs) (16.4%). All MRSA isolates were resistant to erythromycin (98.0%), co-trimoxazole (94.0%) and gentamicin (92.0%). Clindamycin was the best antibiotic with only 6% resistance. All MRSA isolates were sensitive to vancomycin. <b>Conclusion:</b> The rate of nosocomial MRSA infection per 1000 admissions was higher than that in other studies. The three factors associated most significantly with acquired MRSA infections included duration of hospitalization, antibiotic use, and bedside invasive procedures. This study confirmed that vancomycin-resistant <i>S aureus</i> has not yet been established in HUSM.http://www.saudiannals.net/article.asp?issn=0256-4947;year=2010;volume=30;issue=5;spage=358;epage=363;aulast=Al-Talib |
| spellingShingle | Al-Talib Hassanain Yean Chan Al-Jashamy Karim Hasan Habsah Methicillin-resistant <i>Staphylococcus aureus</i> nosocomial infection trends in Hospital Universiti Sains Malaysia during 2002-2007 Annals of Saudi Medicine |
| title | Methicillin-resistant <i>Staphylococcus aureus</i> nosocomial infection trends in Hospital Universiti Sains Malaysia during 2002-2007 |
| title_full | Methicillin-resistant <i>Staphylococcus aureus</i> nosocomial infection trends in Hospital Universiti Sains Malaysia during 2002-2007 |
| title_fullStr | Methicillin-resistant <i>Staphylococcus aureus</i> nosocomial infection trends in Hospital Universiti Sains Malaysia during 2002-2007 |
| title_full_unstemmed | Methicillin-resistant <i>Staphylococcus aureus</i> nosocomial infection trends in Hospital Universiti Sains Malaysia during 2002-2007 |
| title_short | Methicillin-resistant <i>Staphylococcus aureus</i> nosocomial infection trends in Hospital Universiti Sains Malaysia during 2002-2007 |
| title_sort | methicillin resistant i staphylococcus aureus i nosocomial infection trends in hospital universiti sains malaysia during 2002 2007 |
| url | http://www.saudiannals.net/article.asp?issn=0256-4947;year=2010;volume=30;issue=5;spage=358;epage=363;aulast=Al-Talib |
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