MPTP-induced increase in c-Fos- and c-Jun-like immunoreactivity in the monkey cerebellum
The transcription factors c-Fos and c-Jun have been described to be overexpressed following many pathological stimuli, but whether they are required for neurodegeneration or neuroprotection is still open. In the present report, we analyzed the role of c-Fos and c-Jun proteins in Purkinje cell degene...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2009-06-01
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| Series: | European Journal of Histochemistry |
| Online Access: | https://www.ejh.it/index.php/ejh/article/view/912 |
| _version_ | 1818085236370571264 |
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| author | D Necchi C Soldani F Ronchetti G Bernocchi E Scherini |
| author_facet | D Necchi C Soldani F Ronchetti G Bernocchi E Scherini |
| author_sort | D Necchi |
| collection | DOAJ |
| description | The transcription factors c-Fos and c-Jun have been described to be overexpressed following many pathological stimuli, but whether they are required for neurodegeneration or neuroprotection is still open. In the present report, we analyzed the role of c-Fos and c-Jun proteins in Purkinje cell degeneration caused by the neurotoxin MPTP (1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine) in the monkey cerebellum, and determined the neuroprotective effect of the antioxidant drug a-dihydroergocryptine (DHEC), whose prior and simultaneous administration reduced the MPTP-induced neuronal loss in the substantia nigra. Immunocytochemistry for c-Fos- and c-Jun-like proteins showed persistent increased staining in Purkinje cells of MPTP-treated monkeys. The staining was greatly reduced in animals receiving DHEC. Similar results were observed in white matter glial cells after immunoreaction for c-Fos. The results suggest that, at least as far as the cerebellum is concerned, the increase in c-Fos and c-Jun expression correlate with cell damage, rather than with preservation. |
| first_indexed | 2024-12-10T20:06:34Z |
| format | Article |
| id | doaj.art-be23050b888c4f3698222d6e4ba75eba |
| institution | Directory Open Access Journal |
| issn | 1121-760X 2038-8306 |
| language | English |
| last_indexed | 2024-12-10T20:06:34Z |
| publishDate | 2009-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Histochemistry |
| spelling | doaj.art-be23050b888c4f3698222d6e4ba75eba2022-12-22T01:35:23ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062009-06-0148410.4081/912635MPTP-induced increase in c-Fos- and c-Jun-like immunoreactivity in the monkey cerebellumD NecchiC SoldaniF RonchettiG BernocchiE ScheriniThe transcription factors c-Fos and c-Jun have been described to be overexpressed following many pathological stimuli, but whether they are required for neurodegeneration or neuroprotection is still open. In the present report, we analyzed the role of c-Fos and c-Jun proteins in Purkinje cell degeneration caused by the neurotoxin MPTP (1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine) in the monkey cerebellum, and determined the neuroprotective effect of the antioxidant drug a-dihydroergocryptine (DHEC), whose prior and simultaneous administration reduced the MPTP-induced neuronal loss in the substantia nigra. Immunocytochemistry for c-Fos- and c-Jun-like proteins showed persistent increased staining in Purkinje cells of MPTP-treated monkeys. The staining was greatly reduced in animals receiving DHEC. Similar results were observed in white matter glial cells after immunoreaction for c-Fos. The results suggest that, at least as far as the cerebellum is concerned, the increase in c-Fos and c-Jun expression correlate with cell damage, rather than with preservation.https://www.ejh.it/index.php/ejh/article/view/912 |
| spellingShingle | D Necchi C Soldani F Ronchetti G Bernocchi E Scherini MPTP-induced increase in c-Fos- and c-Jun-like immunoreactivity in the monkey cerebellum European Journal of Histochemistry |
| title | MPTP-induced increase in c-Fos- and c-Jun-like immunoreactivity in the monkey cerebellum |
| title_full | MPTP-induced increase in c-Fos- and c-Jun-like immunoreactivity in the monkey cerebellum |
| title_fullStr | MPTP-induced increase in c-Fos- and c-Jun-like immunoreactivity in the monkey cerebellum |
| title_full_unstemmed | MPTP-induced increase in c-Fos- and c-Jun-like immunoreactivity in the monkey cerebellum |
| title_short | MPTP-induced increase in c-Fos- and c-Jun-like immunoreactivity in the monkey cerebellum |
| title_sort | mptp induced increase in c fos and c jun like immunoreactivity in the monkey cerebellum |
| url | https://www.ejh.it/index.php/ejh/article/view/912 |
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