Construction and application of adenoviral vectors
Adenoviral vectors have been widely used as vaccine candidates or potential vaccine candidates against infectious diseases due to the convenience of genome manipulation, their ability to accommodate large exogenous gene fragments, easy access of obtaining high-titer of virus, and high efficiency of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Molecular Therapy: Nucleic Acids |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S216225312300241X |
| _version_ | 1827804777687285760 |
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| author | Hongbo Zhang Hongdan Wang Youcai An Ze Chen |
| author_facet | Hongbo Zhang Hongdan Wang Youcai An Ze Chen |
| author_sort | Hongbo Zhang |
| collection | DOAJ |
| description | Adenoviral vectors have been widely used as vaccine candidates or potential vaccine candidates against infectious diseases due to the convenience of genome manipulation, their ability to accommodate large exogenous gene fragments, easy access of obtaining high-titer of virus, and high efficiency of transduction. At the same time, adenoviral vectors have also been used extensively in clinical research for cancer gene therapy and treatment of diseases caused by a single gene defect. However, application of adenovirus also faces a series of challenges such as poor targeting, strong immune response against the vector itself, and they cannot be used repeatedly. It is believed that these problems will be solved gradually with further research and technological development in related fields. Here, we review the construction methods of adenoviral vectors, including “gutless” adenovirus and discuss application of adenoviral vectors as prophylactic vaccines for infectious pathogens and their application prospects as therapeutic vaccines for cancer and other kinds of chronic infectious disease such as human papillomavirus, hepatitis B virus, and hepatitis C virus. |
| first_indexed | 2024-03-11T21:15:16Z |
| format | Article |
| id | doaj.art-be25618e86f540ff8e29e7964759b878 |
| institution | Directory Open Access Journal |
| issn | 2162-2531 |
| language | English |
| last_indexed | 2024-03-11T21:15:16Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Nucleic Acids |
| spelling | doaj.art-be25618e86f540ff8e29e7964759b8782023-09-29T04:44:04ZengElsevierMolecular Therapy: Nucleic Acids2162-25312023-12-0134102027Construction and application of adenoviral vectorsHongbo Zhang0Hongdan Wang1Youcai An2Ze Chen3Department of Basic Research, Ab&B Bio-Tech CO., LTD. JS, Taizhou, Jiangsu, ChinaDepartment of Basic Research, Ab&B Bio-Tech CO., LTD. JS, Taizhou, Jiangsu, ChinaDepartment of Basic Research, Ab&B Bio-Tech CO., LTD. JS, Taizhou, Jiangsu, ChinaDepartment of Basic Research, Ab&B Bio-Tech CO., LTD. JS, Taizhou, Jiangsu, China; Corresponding author: Ze Chen, Department of Basic Research, Ab&B Bio-Tech CO., LTD. JS, Taizhou, Jiangsu, China.Adenoviral vectors have been widely used as vaccine candidates or potential vaccine candidates against infectious diseases due to the convenience of genome manipulation, their ability to accommodate large exogenous gene fragments, easy access of obtaining high-titer of virus, and high efficiency of transduction. At the same time, adenoviral vectors have also been used extensively in clinical research for cancer gene therapy and treatment of diseases caused by a single gene defect. However, application of adenovirus also faces a series of challenges such as poor targeting, strong immune response against the vector itself, and they cannot be used repeatedly. It is believed that these problems will be solved gradually with further research and technological development in related fields. Here, we review the construction methods of adenoviral vectors, including “gutless” adenovirus and discuss application of adenoviral vectors as prophylactic vaccines for infectious pathogens and their application prospects as therapeutic vaccines for cancer and other kinds of chronic infectious disease such as human papillomavirus, hepatitis B virus, and hepatitis C virus.http://www.sciencedirect.com/science/article/pii/S216225312300241XMT: Delivery Strategiesadenovirusconstruction methodsapplication |
| spellingShingle | Hongbo Zhang Hongdan Wang Youcai An Ze Chen Construction and application of adenoviral vectors Molecular Therapy: Nucleic Acids MT: Delivery Strategies adenovirus construction methods application |
| title | Construction and application of adenoviral vectors |
| title_full | Construction and application of adenoviral vectors |
| title_fullStr | Construction and application of adenoviral vectors |
| title_full_unstemmed | Construction and application of adenoviral vectors |
| title_short | Construction and application of adenoviral vectors |
| title_sort | construction and application of adenoviral vectors |
| topic | MT: Delivery Strategies adenovirus construction methods application |
| url | http://www.sciencedirect.com/science/article/pii/S216225312300241X |
| work_keys_str_mv | AT hongbozhang constructionandapplicationofadenoviralvectors AT hongdanwang constructionandapplicationofadenoviralvectors AT youcaian constructionandapplicationofadenoviralvectors AT zechen constructionandapplicationofadenoviralvectors |