Thalamic structure and anastomosis in different hemispheres of moyamoya disease
ObjectiveThe progression of the asymptomatic hemisphere of moyamoya disease (MMD) is largely unknown. In this study, we investigated the differences in subcortical gray matter structure and angiographic features between asymptomatic and symptomatic hemispheres in patients with MMD.MethodsWe retrospe...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.1058137/full |
| _version_ | 1797956687856926720 |
|---|---|
| author | Junwen Hu Junwen Hu Yongjie Wang Yongjie Wang Yun Tong Gaojun Lin Yin Li Yin Li Jingyin Chen Jingyin Chen Duo Xu Lin Wang Lin Wang Ruiliang Bai Ruiliang Bai Ruiliang Bai |
| author_facet | Junwen Hu Junwen Hu Yongjie Wang Yongjie Wang Yun Tong Gaojun Lin Yin Li Yin Li Jingyin Chen Jingyin Chen Duo Xu Lin Wang Lin Wang Ruiliang Bai Ruiliang Bai Ruiliang Bai |
| author_sort | Junwen Hu |
| collection | DOAJ |
| description | ObjectiveThe progression of the asymptomatic hemisphere of moyamoya disease (MMD) is largely unknown. In this study, we investigated the differences in subcortical gray matter structure and angiographic features between asymptomatic and symptomatic hemispheres in patients with MMD.MethodsWe retrospectively reviewed patients with MMD in consecutive cases in our center. We compared subcortical gray matter volume and three types of collaterals (lenticulostriate anastomosis, thalamic anastomosis, and choroidal anastomosis) between symptomatic and asymptomatic hemispheres. Symptomatic hemispheres were classified as ischemic hemisphere (i-hemisphere) and hemorrhagic hemisphere (h-hemisphere). Asymptomatic hemispheres were classified as contralateral asymptomatic hemisphere of i-hemisphere (ai-hemisphere), contralateral asymptomatic hemisphere of h-hemisphere (ah-hemisphere), bilateral asymptomatic hemispheres in asymptomatic group (aa-hemisphere).ResultsA total of 117 MMD patients were reviewed, and 49 of them met the inclusion criteria, with 98 hemispheres being analyzed. The thalamic volume was found to differ significantly between the i- and ai-hemispheres (P = 0.010), between the i- and ah-hemispheres (P = 0.004), as well as between the h- and ai-hemispheres (P = 0.002), between the h- and ah-hemispheres (P < 0.001). There was a higher incidence of thalamic anastomosis in the ai-hemispheres than i-hemispheres (31.3% vs. 6.3%, P = 0.070), and in the ah-hemispheres than h-hemispheres (29.6% vs. 11.1%, P = 0.088). Additionally, the hemispheres with thalamic anastomosis had a significantly greater volume than those without thalamic anastomosis (P = 0.024). Univariate and multivariate logistic regression analysis showed that thalamic volume was closely associated with thalamic anastomosis.ConclusionThe thalamic volume and the incidence of thalamic anastomosis increase in asymptomatic hemispheres and decrease in symptomatic hemispheres. Combining these two characteristics may be helpful in assessing the risk of stroke in the asymptomatic hemispheres of MMD as well as understanding the pathological evolution of the disease. |
| first_indexed | 2024-04-10T23:52:49Z |
| format | Article |
| id | doaj.art-be2608ccaee44371817c84afd409e9dd |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-10T23:52:49Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-be2608ccaee44371817c84afd409e9dd2023-01-10T15:22:25ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-01-011610.3389/fnins.2022.10581371058137Thalamic structure and anastomosis in different hemispheres of moyamoya diseaseJunwen Hu0Junwen Hu1Yongjie Wang2Yongjie Wang3Yun Tong4Gaojun Lin5Yin Li6Yin Li7Jingyin Chen8Jingyin Chen9Duo Xu10Lin Wang11Lin Wang12Ruiliang Bai13Ruiliang Bai14Ruiliang Bai15Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaClinical Research Center for Neurological Diseases of Zhejiang, Hangzhou, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaClinical Research Center for Neurological Diseases of Zhejiang, Hangzhou, ChinaAffiliated Cixi Hospital of Wenzhou Medical University, Ningbo, ChinaZhejiang University School of Medicine, Hangzhou, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaClinical Research Center for Neurological Diseases of Zhejiang, Hangzhou, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaClinical Research Center for Neurological Diseases of Zhejiang, Hangzhou, ChinaDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaClinical Research Center for Neurological Diseases of Zhejiang, Hangzhou, ChinaKey Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, ChinaDepartment of Physical Medicine and Rehabilitation of the Affiliated Sir Run Run Shaw Hospital and Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Hangzhou, ChinaMOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, ChinaObjectiveThe progression of the asymptomatic hemisphere of moyamoya disease (MMD) is largely unknown. In this study, we investigated the differences in subcortical gray matter structure and angiographic features between asymptomatic and symptomatic hemispheres in patients with MMD.MethodsWe retrospectively reviewed patients with MMD in consecutive cases in our center. We compared subcortical gray matter volume and three types of collaterals (lenticulostriate anastomosis, thalamic anastomosis, and choroidal anastomosis) between symptomatic and asymptomatic hemispheres. Symptomatic hemispheres were classified as ischemic hemisphere (i-hemisphere) and hemorrhagic hemisphere (h-hemisphere). Asymptomatic hemispheres were classified as contralateral asymptomatic hemisphere of i-hemisphere (ai-hemisphere), contralateral asymptomatic hemisphere of h-hemisphere (ah-hemisphere), bilateral asymptomatic hemispheres in asymptomatic group (aa-hemisphere).ResultsA total of 117 MMD patients were reviewed, and 49 of them met the inclusion criteria, with 98 hemispheres being analyzed. The thalamic volume was found to differ significantly between the i- and ai-hemispheres (P = 0.010), between the i- and ah-hemispheres (P = 0.004), as well as between the h- and ai-hemispheres (P = 0.002), between the h- and ah-hemispheres (P < 0.001). There was a higher incidence of thalamic anastomosis in the ai-hemispheres than i-hemispheres (31.3% vs. 6.3%, P = 0.070), and in the ah-hemispheres than h-hemispheres (29.6% vs. 11.1%, P = 0.088). Additionally, the hemispheres with thalamic anastomosis had a significantly greater volume than those without thalamic anastomosis (P = 0.024). Univariate and multivariate logistic regression analysis showed that thalamic volume was closely associated with thalamic anastomosis.ConclusionThe thalamic volume and the incidence of thalamic anastomosis increase in asymptomatic hemispheres and decrease in symptomatic hemispheres. Combining these two characteristics may be helpful in assessing the risk of stroke in the asymptomatic hemispheres of MMD as well as understanding the pathological evolution of the disease.https://www.frontiersin.org/articles/10.3389/fnins.2022.1058137/fullmoyamoya diseasebrain structurecerebral angiographyanastomosisthalamus |
| spellingShingle | Junwen Hu Junwen Hu Yongjie Wang Yongjie Wang Yun Tong Gaojun Lin Yin Li Yin Li Jingyin Chen Jingyin Chen Duo Xu Lin Wang Lin Wang Ruiliang Bai Ruiliang Bai Ruiliang Bai Thalamic structure and anastomosis in different hemispheres of moyamoya disease Frontiers in Neuroscience moyamoya disease brain structure cerebral angiography anastomosis thalamus |
| title | Thalamic structure and anastomosis in different hemispheres of moyamoya disease |
| title_full | Thalamic structure and anastomosis in different hemispheres of moyamoya disease |
| title_fullStr | Thalamic structure and anastomosis in different hemispheres of moyamoya disease |
| title_full_unstemmed | Thalamic structure and anastomosis in different hemispheres of moyamoya disease |
| title_short | Thalamic structure and anastomosis in different hemispheres of moyamoya disease |
| title_sort | thalamic structure and anastomosis in different hemispheres of moyamoya disease |
| topic | moyamoya disease brain structure cerebral angiography anastomosis thalamus |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.1058137/full |
| work_keys_str_mv | AT junwenhu thalamicstructureandanastomosisindifferenthemispheresofmoyamoyadisease AT junwenhu thalamicstructureandanastomosisindifferenthemispheresofmoyamoyadisease AT yongjiewang thalamicstructureandanastomosisindifferenthemispheresofmoyamoyadisease AT yongjiewang thalamicstructureandanastomosisindifferenthemispheresofmoyamoyadisease AT yuntong thalamicstructureandanastomosisindifferenthemispheresofmoyamoyadisease AT gaojunlin thalamicstructureandanastomosisindifferenthemispheresofmoyamoyadisease AT yinli thalamicstructureandanastomosisindifferenthemispheresofmoyamoyadisease AT yinli thalamicstructureandanastomosisindifferenthemispheresofmoyamoyadisease AT jingyinchen thalamicstructureandanastomosisindifferenthemispheresofmoyamoyadisease AT jingyinchen thalamicstructureandanastomosisindifferenthemispheresofmoyamoyadisease AT duoxu thalamicstructureandanastomosisindifferenthemispheresofmoyamoyadisease AT linwang thalamicstructureandanastomosisindifferenthemispheresofmoyamoyadisease AT linwang thalamicstructureandanastomosisindifferenthemispheresofmoyamoyadisease AT ruiliangbai thalamicstructureandanastomosisindifferenthemispheresofmoyamoyadisease AT ruiliangbai thalamicstructureandanastomosisindifferenthemispheresofmoyamoyadisease AT ruiliangbai thalamicstructureandanastomosisindifferenthemispheresofmoyamoyadisease |