| Summary: | Regenerative Peripheral Nerve Interface represents a surgical technique, whereby a free muscle graft is utilized as a physiological ‘target’ for peripheral nerve ingrowth. This procedure was first developed for increasing the amplitude of motor nerve signals to control neuro-prosthetic devices. Regenerative Peripheral Nerve Interface has since been broadened for painful stump neuroma management in amputees, in addition to further optimizing advances in neuro-prosthetic function. To the best of our knowledge, this paper presents two cases, with the first documented use of Regenerative Peripheral Nerve Interface, as an innovative technique for the management of iatrogenic, symptomatic neuroma in-continuity complications involving the forefoot.
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