Comparative Analysis of Genetic Alterations, HPV-Status, and PD-L1 Expression in Neuroendocrine Carcinomas of the Cervix

Comparative Analysis of Genetic Alterations, HPV-Status, and PD-L1 Expression in Neuroendocrine Carcinomas of the Cervix

Neuroendocrine carcinoma of the cervix (NECC) is a rare and highly aggressive tumor with no efficient treatment. We examined genetic features of NECC and identified potential therapeutic targets. A total of 272 patients with cervical cancer (25 NECC, 180 squamous cell carcinoma, 53 adenocarcinoma, a...

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Bibliographic Details
Main Authors: Daisuke Takayanagi, Sou Hirose, Ikumi Kuno, Yuka Asami, Naoya Murakami, Maiko Matsuda, Yoko Shimada, Kuniko Sunami, Masaaki Komatsu, Ryuji Hamamoto, Mayumi Kobayashi Kato, Koji Matsumoto, Takashi Kohno, Tomoyasu Kato, Kouya Shiraishi, Hiroshi Yoshida
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
neuroendocrine carcinomas
cervical cancer
next-generation sequencing
targeted therapy
HPV
PD-L1
Online Access:https://www.mdpi.com/2072-6694/13/6/1215

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