Acute peripheral immune activation alters cytokine expression and glial activation in the early postnatal rat brain

Acute peripheral immune activation alters cytokine expression and glial activation in the early postnatal rat brain

Abstract Background Neuroinflammation can modulate brain development; however, the influence of an acute peripheral immune challenge on neuroinflammatory responses in the early postnatal brain is not well characterized. To address this gap in knowledge, we evaluated the peripheral and central nervou...

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Bibliographic Details
Main Authors: Matthew Bruce, Karin M. Streifel, Casey A. Boosalis, Luke Heuer, Eduardo A. González, Shuyang Li, Danielle J. Harvey, Pamela J. Lein, Judy Van de Water
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Neuroinflammation
Subjects:
Rat model
Cytokines
Microglia
Astrocytes
Sex differences
Peripheral immune challenge
Online Access:http://link.springer.com/article/10.1186/s12974-019-1569-2

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