Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines
This paper reports the synthesis of phenyl-substituted 2-alkoxy(methylsulfanyl)-1,2,4-triazolo[1,5-a]quinazolines starting from N-cyanoimidocarbonates and substituted hydrazinobenzoic acids as building blocks. Thionation or chlorination of the inherent lactam moiety in the target compounds followed...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-10-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/15/10/7016/ |
| _version_ | 1819115666532204544 |
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| author | Rashad A. Al-Salahi |
| author_facet | Rashad A. Al-Salahi |
| author_sort | Rashad A. Al-Salahi |
| collection | DOAJ |
| description | This paper reports the synthesis of phenyl-substituted 2-alkoxy(methylsulfanyl)-1,2,4-triazolo[1,5-a]quinazolines starting from N-cyanoimidocarbonates and substituted hydrazinobenzoic acids as building blocks. Thionation or chlorination of the inherent lactam moiety in the target compounds followed by treatment with multifunctional nucleophiles provided access to a variety of derivatives. |
| first_indexed | 2024-12-22T05:04:49Z |
| format | Article |
| id | doaj.art-be2ab3c2a96745308550a683533a7698 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T05:04:49Z |
| publishDate | 2010-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-be2ab3c2a96745308550a683533a76982022-12-21T18:38:08ZengMDPI AGMolecules1420-30492010-10-0115107016703410.3390/molecules15107016Synthesis and Reactivity of [1,2,4]Triazolo-annelated QuinazolinesRashad A. Al-SalahiThis paper reports the synthesis of phenyl-substituted 2-alkoxy(methylsulfanyl)-1,2,4-triazolo[1,5-a]quinazolines starting from N-cyanoimidocarbonates and substituted hydrazinobenzoic acids as building blocks. Thionation or chlorination of the inherent lactam moiety in the target compounds followed by treatment with multifunctional nucleophiles provided access to a variety of derivatives.http://www.mdpi.com/1420-3049/15/10/7016/triazolo[1,5-a]quinazolinesthionationalkylationchlorinationtetracyclic systems |
| spellingShingle | Rashad A. Al-Salahi Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines Molecules triazolo[1,5-a]quinazolines thionation alkylation chlorination tetracyclic systems |
| title | Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines |
| title_full | Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines |
| title_fullStr | Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines |
| title_full_unstemmed | Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines |
| title_short | Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines |
| title_sort | synthesis and reactivity of 1 2 4 triazolo annelated quinazolines |
| topic | triazolo[1,5-a]quinazolines thionation alkylation chlorination tetracyclic systems |
| url | http://www.mdpi.com/1420-3049/15/10/7016/ |
| work_keys_str_mv | AT rashadaalsalahi synthesisandreactivityof124triazoloannelatedquinazolines |