The PI3K/Akt pathway in tumors of endocrine tissues
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a key driver in carcinogenesis. Defects in this pathway in human cancer syndromes such as Cowden’s disease and Multiple Endocrine Neoplasia result in tumors of endocrine tissues, highlighting its importance in these cancer types. This review ex...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-01-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00188/full |
| _version_ | 1818288543947030528 |
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| author | Helen Louise Robbins Angela eHague Angela eHague |
| author_facet | Helen Louise Robbins Angela eHague Angela eHague |
| author_sort | Helen Louise Robbins |
| collection | DOAJ |
| description | The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a key driver in carcinogenesis. Defects in this pathway in human cancer syndromes such as Cowden’s disease and Multiple Endocrine Neoplasia result in tumors of endocrine tissues, highlighting its importance in these cancer types. This review explores the growing evidence from multiple animal and in vitro models and from analysis of human tumors for the involvement of this pathway in the following: thyroid carcinoma subtypes, parathyroid carcinoma, pituitary tumors, adrenocortical carcinoma, phaeochromocytoma, neuroblastoma, and gastroenteropancreatic neuroendocrine tumors. Whilst data are not always consistent, immunohistochemistry performed on human tumor tissue has been used alongside other techniques to demonstrate Akt overactivation. We review active Akt as a potential prognostic marker and the PI3K pathway as a therapeutic target in endocrine neoplasia. |
| first_indexed | 2024-12-13T01:58:04Z |
| format | Article |
| id | doaj.art-be2e1259f8f54e6ba4d8bbf88acef32a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-13T01:58:04Z |
| publishDate | 2016-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-be2e1259f8f54e6ba4d8bbf88acef32a2022-12-22T00:03:20ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922016-01-01610.3389/fendo.2015.00188174816The PI3K/Akt pathway in tumors of endocrine tissuesHelen Louise Robbins0Angela eHague1Angela eHague2University Hospital Coventry and WarwickshireUniversity of BristolUniversity of BristolThe phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a key driver in carcinogenesis. Defects in this pathway in human cancer syndromes such as Cowden’s disease and Multiple Endocrine Neoplasia result in tumors of endocrine tissues, highlighting its importance in these cancer types. This review explores the growing evidence from multiple animal and in vitro models and from analysis of human tumors for the involvement of this pathway in the following: thyroid carcinoma subtypes, parathyroid carcinoma, pituitary tumors, adrenocortical carcinoma, phaeochromocytoma, neuroblastoma, and gastroenteropancreatic neuroendocrine tumors. Whilst data are not always consistent, immunohistochemistry performed on human tumor tissue has been used alongside other techniques to demonstrate Akt overactivation. We review active Akt as a potential prognostic marker and the PI3K pathway as a therapeutic target in endocrine neoplasia.http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00188/fullAdrenocortical CarcinomaNeuroblastomaPheochromocytomapituitary tumorsAkt (PKB)Gastroenteropancreatic neuroendocrine tumors |
| spellingShingle | Helen Louise Robbins Angela eHague Angela eHague The PI3K/Akt pathway in tumors of endocrine tissues Frontiers in Endocrinology Adrenocortical Carcinoma Neuroblastoma Pheochromocytoma pituitary tumors Akt (PKB) Gastroenteropancreatic neuroendocrine tumors |
| title | The PI3K/Akt pathway in tumors of endocrine tissues |
| title_full | The PI3K/Akt pathway in tumors of endocrine tissues |
| title_fullStr | The PI3K/Akt pathway in tumors of endocrine tissues |
| title_full_unstemmed | The PI3K/Akt pathway in tumors of endocrine tissues |
| title_short | The PI3K/Akt pathway in tumors of endocrine tissues |
| title_sort | pi3k akt pathway in tumors of endocrine tissues |
| topic | Adrenocortical Carcinoma Neuroblastoma Pheochromocytoma pituitary tumors Akt (PKB) Gastroenteropancreatic neuroendocrine tumors |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00188/full |
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