Ninety-day repeated oral toxicity study of saponified Capsicum annum fruit extract with 50% capsanthin in Sprague-Dawley Rats with a 28-day recovery period
Abstracts: A ninety-day oral toxicity study of saponified Capsicum annum fruit extract with 50% (w/w) capsanthin (SCFE-50 C) was performed by oral gavage administration to male and female Sprague-Dawley (SD) rats at doses of 0, 500, 1000 and 2000 mg/kg BW/day for a period of ninety consecutive days....
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750022000312 |
| _version_ | 1811293969447911424 |
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| author | Velmurugan Shanmugham Ravi Subban |
| author_facet | Velmurugan Shanmugham Ravi Subban |
| author_sort | Velmurugan Shanmugham |
| collection | DOAJ |
| description | Abstracts: A ninety-day oral toxicity study of saponified Capsicum annum fruit extract with 50% (w/w) capsanthin (SCFE-50 C) was performed by oral gavage administration to male and female Sprague-Dawley (SD) rats at doses of 0, 500, 1000 and 2000 mg/kg BW/day for a period of ninety consecutive days. To assess the reversal of toxicity, the treatment phase was followed with a twenty-eight-day recovery period. The treatment with SCFE-50 C in both male and female SD rats showed no mortality, and no treatment-related toxicologically significant changes were observed in any groups. No significant differences between treated and control groups were found in feed consumption, body weight gain, individual organ weights, ocular examination, clinical chemistry or blood biochemistry. The necroscopy and histopathology examination did not reveal any clinically significant changes in male and female rats from the 2000 mg/kg BW/day group. According to this study, the no observable adverse effect level (NOAEL) for saponified Capsicum annum fruit extract with 50% (w/w) capsanthin (SCFE-50 C) administered by oral gavage for 90-days is > 2000 mg/kg BW/day in SD rats. |
| first_indexed | 2024-04-13T05:09:25Z |
| format | Article |
| id | doaj.art-be2e29558d7a4a0eaa96041486faf578 |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-04-13T05:09:25Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-be2e29558d7a4a0eaa96041486faf5782022-12-22T03:01:04ZengElsevierToxicology Reports2214-75002022-01-019323336Ninety-day repeated oral toxicity study of saponified Capsicum annum fruit extract with 50% capsanthin in Sprague-Dawley Rats with a 28-day recovery periodVelmurugan Shanmugham0Ravi Subban1Corresponding author.; Department of Chemistry, Karpagam Academy of Higher Education, Coimbatore 641021, IndiaDepartment of Chemistry, Karpagam Academy of Higher Education, Coimbatore 641021, IndiaAbstracts: A ninety-day oral toxicity study of saponified Capsicum annum fruit extract with 50% (w/w) capsanthin (SCFE-50 C) was performed by oral gavage administration to male and female Sprague-Dawley (SD) rats at doses of 0, 500, 1000 and 2000 mg/kg BW/day for a period of ninety consecutive days. To assess the reversal of toxicity, the treatment phase was followed with a twenty-eight-day recovery period. The treatment with SCFE-50 C in both male and female SD rats showed no mortality, and no treatment-related toxicologically significant changes were observed in any groups. No significant differences between treated and control groups were found in feed consumption, body weight gain, individual organ weights, ocular examination, clinical chemistry or blood biochemistry. The necroscopy and histopathology examination did not reveal any clinically significant changes in male and female rats from the 2000 mg/kg BW/day group. According to this study, the no observable adverse effect level (NOAEL) for saponified Capsicum annum fruit extract with 50% (w/w) capsanthin (SCFE-50 C) administered by oral gavage for 90-days is > 2000 mg/kg BW/day in SD rats.http://www.sciencedirect.com/science/article/pii/S2214750022000312Saponified Capsicum annum fruit extractCapsicum annumCapsanthin 50% w/wToxicitySD RatsNOAEL |
| spellingShingle | Velmurugan Shanmugham Ravi Subban Ninety-day repeated oral toxicity study of saponified Capsicum annum fruit extract with 50% capsanthin in Sprague-Dawley Rats with a 28-day recovery period Toxicology Reports Saponified Capsicum annum fruit extract Capsicum annum Capsanthin 50% w/w Toxicity SD Rats NOAEL |
| title | Ninety-day repeated oral toxicity study of saponified Capsicum annum fruit extract with 50% capsanthin in Sprague-Dawley Rats with a 28-day recovery period |
| title_full | Ninety-day repeated oral toxicity study of saponified Capsicum annum fruit extract with 50% capsanthin in Sprague-Dawley Rats with a 28-day recovery period |
| title_fullStr | Ninety-day repeated oral toxicity study of saponified Capsicum annum fruit extract with 50% capsanthin in Sprague-Dawley Rats with a 28-day recovery period |
| title_full_unstemmed | Ninety-day repeated oral toxicity study of saponified Capsicum annum fruit extract with 50% capsanthin in Sprague-Dawley Rats with a 28-day recovery period |
| title_short | Ninety-day repeated oral toxicity study of saponified Capsicum annum fruit extract with 50% capsanthin in Sprague-Dawley Rats with a 28-day recovery period |
| title_sort | ninety day repeated oral toxicity study of saponified capsicum annum fruit extract with 50 capsanthin in sprague dawley rats with a 28 day recovery period |
| topic | Saponified Capsicum annum fruit extract Capsicum annum Capsanthin 50% w/w Toxicity SD Rats NOAEL |
| url | http://www.sciencedirect.com/science/article/pii/S2214750022000312 |
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