Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Cats With Hypertrophic Cardiomyopathy
ObjectiveTo assess the prognostic value of neutrophil-to-lymphocyte ratio (NLR) for cardiac death in cats with hypertrophic cardiomyopathy.Study DesignProspective observation study.AnimalsNinety-six client-owned cats.MethodsComplete blood count samples were collected from 38 healthy and 58 cats with...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
|
| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2022.813524/full |
| _version_ | 1819120691760332800 |
|---|---|
| author | Ryan C. Fries Saki Kadotani Jonathan P. Stack Jonathan P. Stack Leah Kruckman Gabrielle Wallace Gabrielle Wallace |
| author_facet | Ryan C. Fries Saki Kadotani Jonathan P. Stack Jonathan P. Stack Leah Kruckman Gabrielle Wallace Gabrielle Wallace |
| author_sort | Ryan C. Fries |
| collection | DOAJ |
| description | ObjectiveTo assess the prognostic value of neutrophil-to-lymphocyte ratio (NLR) for cardiac death in cats with hypertrophic cardiomyopathy.Study DesignProspective observation study.AnimalsNinety-six client-owned cats.MethodsComplete blood count samples were collected from 38 healthy and 58 cats with hypertrophic cardiomyopathy (HCM), and the NLR ratios were analyzed. All cats had echocardiographic measurements performed on the same day as blood collection. Spearman rank correlation was used to assess the relationship between echocardiographic measurements and NLR. Long-term outcome data were obtained, and time to cardiac death and variables associated with cardiac death were analyzed using Kaplan–Meier survival curves and Cox proportional hazards models, respectively.ResultsThe NLR was significantly higher in cats with confirmed congestive heart failure. When evaluating HCM patients, cats in the third NLR tertile had a significantly higher risk of cardiac death with a hazard ratio of 10.26 (95% CI: 1.84–57.14; p = 0.0001) when compared with that of patients in the first tertile. NLR was significantly associated with echocardiographic measures of left atrial size, left auricular function, the presence of left atrial spontaneous echo contrast (SEC), and thrombus formation.Conclusions and Clinical RelevanceIncreased NLR is a negative prognostic indicator in cats with HCM. |
| first_indexed | 2024-12-22T06:24:42Z |
| format | Article |
| id | doaj.art-be303cff52234457ab723a1272dab9f0 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-12-22T06:24:42Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-be303cff52234457ab723a1272dab9f02022-12-21T18:35:52ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692022-03-01910.3389/fvets.2022.813524813524Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Cats With Hypertrophic CardiomyopathyRyan C. Fries0Saki Kadotani1Jonathan P. Stack2Jonathan P. Stack3Leah Kruckman4Gabrielle Wallace5Gabrielle Wallace6Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, United StatesDepartment of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, United StatesDepartment of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, United StatesVCA Loomis Basin Veterinary Clinic, Loomis, CA, United StatesDepartment of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, United StatesDepartment of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, United StatesPacific Northwest Pet ER and Specialty Center, Vancouver, WA, United StatesObjectiveTo assess the prognostic value of neutrophil-to-lymphocyte ratio (NLR) for cardiac death in cats with hypertrophic cardiomyopathy.Study DesignProspective observation study.AnimalsNinety-six client-owned cats.MethodsComplete blood count samples were collected from 38 healthy and 58 cats with hypertrophic cardiomyopathy (HCM), and the NLR ratios were analyzed. All cats had echocardiographic measurements performed on the same day as blood collection. Spearman rank correlation was used to assess the relationship between echocardiographic measurements and NLR. Long-term outcome data were obtained, and time to cardiac death and variables associated with cardiac death were analyzed using Kaplan–Meier survival curves and Cox proportional hazards models, respectively.ResultsThe NLR was significantly higher in cats with confirmed congestive heart failure. When evaluating HCM patients, cats in the third NLR tertile had a significantly higher risk of cardiac death with a hazard ratio of 10.26 (95% CI: 1.84–57.14; p = 0.0001) when compared with that of patients in the first tertile. NLR was significantly associated with echocardiographic measures of left atrial size, left auricular function, the presence of left atrial spontaneous echo contrast (SEC), and thrombus formation.Conclusions and Clinical RelevanceIncreased NLR is a negative prognostic indicator in cats with HCM.https://www.frontiersin.org/articles/10.3389/fvets.2022.813524/fullmortalityinflammationneutrophil-to-lymphocyte ratioprognosishypertrophic |
| spellingShingle | Ryan C. Fries Saki Kadotani Jonathan P. Stack Jonathan P. Stack Leah Kruckman Gabrielle Wallace Gabrielle Wallace Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Cats With Hypertrophic Cardiomyopathy Frontiers in Veterinary Science mortality inflammation neutrophil-to-lymphocyte ratio prognosis hypertrophic |
| title | Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Cats With Hypertrophic Cardiomyopathy |
| title_full | Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Cats With Hypertrophic Cardiomyopathy |
| title_fullStr | Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Cats With Hypertrophic Cardiomyopathy |
| title_full_unstemmed | Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Cats With Hypertrophic Cardiomyopathy |
| title_short | Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Cats With Hypertrophic Cardiomyopathy |
| title_sort | prognostic value of neutrophil to lymphocyte ratio in cats with hypertrophic cardiomyopathy |
| topic | mortality inflammation neutrophil-to-lymphocyte ratio prognosis hypertrophic |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2022.813524/full |
| work_keys_str_mv | AT ryancfries prognosticvalueofneutrophiltolymphocyteratioincatswithhypertrophiccardiomyopathy AT sakikadotani prognosticvalueofneutrophiltolymphocyteratioincatswithhypertrophiccardiomyopathy AT jonathanpstack prognosticvalueofneutrophiltolymphocyteratioincatswithhypertrophiccardiomyopathy AT jonathanpstack prognosticvalueofneutrophiltolymphocyteratioincatswithhypertrophiccardiomyopathy AT leahkruckman prognosticvalueofneutrophiltolymphocyteratioincatswithhypertrophiccardiomyopathy AT gabriellewallace prognosticvalueofneutrophiltolymphocyteratioincatswithhypertrophiccardiomyopathy AT gabriellewallace prognosticvalueofneutrophiltolymphocyteratioincatswithhypertrophiccardiomyopathy |