Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study
Background : Cardiovascular disease and chronic kidney disease share several common risk factors. The Framingham risk score is hypothesized to predict chronic kidney disease development. We determined if the Framingham risk scoring system can correctly predict incident chronic kidney disease in the...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Korean Society of Nephrology
2019-03-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | https://doi.org/10.23876/j.krcp.18.0118 |
| _version_ | 1818422080760184832 |
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| author | Changhyun Lee Hae-Ryong Yun Young Su Joo Sangmi Lee Joohwan Kim Ki Heon Nam Jong Hyun Jhee Jung Tak Park Tae-Hyun Yoo Shin-Wook Kang Seung Hyeok Han |
| author_facet | Changhyun Lee Hae-Ryong Yun Young Su Joo Sangmi Lee Joohwan Kim Ki Heon Nam Jong Hyun Jhee Jung Tak Park Tae-Hyun Yoo Shin-Wook Kang Seung Hyeok Han |
| author_sort | Changhyun Lee |
| collection | DOAJ |
| description | Background :
Cardiovascular disease and chronic kidney disease share several common risk factors. The Framingham risk score is hypothesized to predict chronic kidney disease development. We determined if the Framingham risk scoring system can correctly predict incident chronic kidney disease in the general population.
Methods :
This study included 9,080 subjects who participated in the Korean Genome and Epidemiology Study between 2001 and 2014 and had normal renal function. The subjects were classified into low- (< 10%), intermediate- (10-20%), and high- (> 20%) risk groups based on baseline Framingham risk scores. The primary endpoint was de novo chronic kidney disease development (estimated glomerular filtration rate [eGFR], < 60 mL/min/1.73 m2).
Results :
During a mean follow-up duration of 8.9 ± 4.3 years, 312 (5.3%), 217 (10.8%), and 205 (16.9%) subjects developed chronic kidney disease in the low, intermediate, and high risk groups, respectively (P < 0.001). Multivariable analysis after adjustment for confounding factors showed the hazard ratios for the high- and intermediate risk groups were 2.674 (95% confidence interval [CI], 2.197-3.255) and 1.734 (95% CI, 1.447-2.078), respectively. This association was consistently observed irrespective of proteinuria, age, sex, obesity, or hypertension. The predictive power of this scoring system was lower than that of renal parameters, such as eGFR and proteinuria, but increased when both were included in the prediction model.
Conclusion :
The Framingham risk score predicted incident chronic kidney disease and enhanced risk stratification in conjunction with traditional renal parameters in the general population with normal renal function. |
| first_indexed | 2024-12-14T13:20:34Z |
| format | Article |
| id | doaj.art-be325bcbed154530aa7ab9d050e06ec0 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 |
| language | English |
| last_indexed | 2024-12-14T13:20:34Z |
| publishDate | 2019-03-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-be325bcbed154530aa7ab9d050e06ec02022-12-21T22:59:56ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322019-03-01381495910.23876/j.krcp.18.0118j.krcp.18.0118Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort studyChanghyun Lee0Hae-Ryong Yun1Young Su Joo2Sangmi Lee3Joohwan Kim4Ki Heon Nam5Jong Hyun Jhee6Jung Tak Park7Tae-Hyun Yoo8Shin-Wook Kang9Seung Hyeok Han10Department of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, KoreaDivision of Nephrology and Hypertension, Department of Internal Medicine, Inha University School of Medicine, Incheon, KoreaDepartment of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, KoreaBackground : Cardiovascular disease and chronic kidney disease share several common risk factors. The Framingham risk score is hypothesized to predict chronic kidney disease development. We determined if the Framingham risk scoring system can correctly predict incident chronic kidney disease in the general population. Methods : This study included 9,080 subjects who participated in the Korean Genome and Epidemiology Study between 2001 and 2014 and had normal renal function. The subjects were classified into low- (< 10%), intermediate- (10-20%), and high- (> 20%) risk groups based on baseline Framingham risk scores. The primary endpoint was de novo chronic kidney disease development (estimated glomerular filtration rate [eGFR], < 60 mL/min/1.73 m2). Results : During a mean follow-up duration of 8.9 ± 4.3 years, 312 (5.3%), 217 (10.8%), and 205 (16.9%) subjects developed chronic kidney disease in the low, intermediate, and high risk groups, respectively (P < 0.001). Multivariable analysis after adjustment for confounding factors showed the hazard ratios for the high- and intermediate risk groups were 2.674 (95% confidence interval [CI], 2.197-3.255) and 1.734 (95% CI, 1.447-2.078), respectively. This association was consistently observed irrespective of proteinuria, age, sex, obesity, or hypertension. The predictive power of this scoring system was lower than that of renal parameters, such as eGFR and proteinuria, but increased when both were included in the prediction model. Conclusion : The Framingham risk score predicted incident chronic kidney disease and enhanced risk stratification in conjunction with traditional renal parameters in the general population with normal renal function.https://doi.org/10.23876/j.krcp.18.0118Chronic kidney diseaseFramingham risk scoreKorean Genome and Epidemiology StudyProteinuria |
| spellingShingle | Changhyun Lee Hae-Ryong Yun Young Su Joo Sangmi Lee Joohwan Kim Ki Heon Nam Jong Hyun Jhee Jung Tak Park Tae-Hyun Yoo Shin-Wook Kang Seung Hyeok Han Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study Kidney Research and Clinical Practice Chronic kidney disease Framingham risk score Korean Genome and Epidemiology Study Proteinuria |
| title | Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study |
| title_full | Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study |
| title_fullStr | Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study |
| title_full_unstemmed | Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study |
| title_short | Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study |
| title_sort | framingham risk score and risk of incident chronic kidney disease a community based prospective cohort study |
| topic | Chronic kidney disease Framingham risk score Korean Genome and Epidemiology Study Proteinuria |
| url | https://doi.org/10.23876/j.krcp.18.0118 |
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