Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System
Involvement of the central nervous system, although uncommon, is one of the most frequent extramedullary manifestations of chronic lymphocytic leukaemia (CLL). Various conditions can lead to neurological symptoms in CLL patients and distinguishing between clinically significant CLL involvement of th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SMC MEDIA SRL
2021-11-01
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| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/2847 |
| _version_ | 1818736702109253632 |
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| author | Carolina Amado Valter Duarte Mariana Silva Leal Margarida Cruz Gisela Ferreira |
| author_facet | Carolina Amado Valter Duarte Mariana Silva Leal Margarida Cruz Gisela Ferreira |
| author_sort | Carolina Amado |
| collection | DOAJ |
| description | Involvement of the central nervous system, although uncommon, is one of the most frequent extramedullary manifestations of chronic lymphocytic leukaemia (CLL). Various conditions can lead to neurological symptoms in CLL patients and distinguishing between clinically significant CLL involvement of the CNS and other aetiologies can be challenging.
The authors report the case of a 90-year-old woman with a previous diagnosis of low-risk CLL who presented to the emergency room with altered mental status. After the most frequent causes were ruled out and considering the underlying disease, CNS infiltration by clonal B-cells was hypothesised and later confirmed. Treatment was initiated, but the patient died soon afterwards. |
| first_indexed | 2024-12-18T00:41:21Z |
| format | Article |
| id | doaj.art-be33cb8557e540b1baa9d48cb9cf8ebe |
| institution | Directory Open Access Journal |
| issn | 2284-2594 |
| language | English |
| last_indexed | 2024-12-18T00:41:21Z |
| publishDate | 2021-11-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj.art-be33cb8557e540b1baa9d48cb9cf8ebe2022-12-21T21:26:53ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942021-11-0110.12890/2021_0028472463Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous SystemCarolina Amado0Valter Duarte1Mariana Silva Leal2Margarida Cruz3Gisela Ferreira4Internal Medicine Department, Centro Hospitalar do Baixo Vouga, Aveiro, PortugalInternal Medicine Department, Centro Hospitalar do Baixo Vouga, Aveiro, PortugalInternal Medicine Department, Centro Hospitalar do Baixo Vouga, Aveiro, PortugalInternal Medicine Department, Centro Hospitalar do Baixo Vouga, Aveiro, PortugalHaematology Department, Centro Hospitalar do Baixo Vouga, Aveiro, PortugalInvolvement of the central nervous system, although uncommon, is one of the most frequent extramedullary manifestations of chronic lymphocytic leukaemia (CLL). Various conditions can lead to neurological symptoms in CLL patients and distinguishing between clinically significant CLL involvement of the CNS and other aetiologies can be challenging. The authors report the case of a 90-year-old woman with a previous diagnosis of low-risk CLL who presented to the emergency room with altered mental status. After the most frequent causes were ruled out and considering the underlying disease, CNS infiltration by clonal B-cells was hypothesised and later confirmed. Treatment was initiated, but the patient died soon afterwards.https://www.ejcrim.com/index.php/EJCRIM/article/view/2847chronic lymphocytic leukaemiacentral nervous system |
| spellingShingle | Carolina Amado Valter Duarte Mariana Silva Leal Margarida Cruz Gisela Ferreira Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System European Journal of Case Reports in Internal Medicine chronic lymphocytic leukaemia central nervous system |
| title | Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System |
| title_full | Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System |
| title_fullStr | Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System |
| title_full_unstemmed | Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System |
| title_short | Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System |
| title_sort | chronic lymphocytic leukaemia rare involvement of the central nervous system |
| topic | chronic lymphocytic leukaemia central nervous system |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/2847 |
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