Guanxin Danshen Formulation Protects against Myocardial Ischemia Reperfusion Injury-Induced Left Ventricular Remodeling by Upregulating Estrogen Receptor β

Guanxin Danshen Formulation Protects against Myocardial Ischemia Reperfusion Injury-Induced Left Ventricular Remodeling by Upregulating Estrogen Receptor β

Background: Guanxin Danshen formulation (GXDSF) is a traditional Chinese herbal recipe recorded in the Chinese Pharmacopeia since 1995 edition, which consists of Salviae miltiorrhizae Radix et Rhizoma, Notoginseng Radix et Rhizoma and Dalbergiae odoriferae Lignum. Our previous research suggested GXD...

Full description

Bibliographic Details
Main Authors:	Xuehong Deng, Xiaoyan Xing, Guibo Sun, Xudong Xu, Haifeng Wu, Guang Li, Xiaobo Sun
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-11-01
Series:	Frontiers in Pharmacology
Subjects:	Guanxin Danshen formula myocardial ischemia reperfusion injury ventricular remodeling network pharmacology estrogen receptor β PI3K/Akt
Online Access:	http://journal.frontiersin.org/article/10.3389/fphar.2017.00777/full

Similar Items

Protective effect of Guanxin Danshen formula on myocardial ischemiareperfusion injury in rats
by: Lanfang Li, et al.
Published: (2023-04-01)

Long Non-Coding RNA-Mediated Competing Endogenous RNA Networks in Ischemic Stroke: Molecular Mechanisms, Therapeutic Implications, and Challenges
by: Shuxia Zhang, et al.
Published: (2021-11-01)

Targeting Calcium Homeostasis in Myocardial Ischemia/Reperfusion Injury: An Overview of Regulatory Mechanisms and Therapeutic Reagents
by: Ruiying Wang, et al.
Published: (2020-06-01)

Saponins in Chinese Herbal Medicine Exerts Protection in Myocardial Ischemia–Reperfusion Injury: Possible Mechanism and Target Analysis
by: Ruiying Wang, et al.
Published: (2021-01-01)

Notoginsenoside R1 Protects Against Diabetic Cardiomyopathy Through Activating Estrogen Receptor α and Its Downstream Signaling
by: Bin Zhang, et al.
Published: (2018-11-01)

Gypenoside XVII protects against myocardial ischemia and reperfusion injury by inhibiting ER stress–induced mitochondrial injury
by: Yingli Yu, et al.
Published: (2021-11-01)

Neuroprotective Effects of Radix Scrophulariae on Cerebral Ischemia and Reperfusion Injury via MAPK Pathways
by: Xiangbao Meng, et al.
Published: (2018-09-01)

Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia–reperfusion injury
by: Shan Lu, et al.
Published: (2021-03-01)

Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies
by: Weijie Xie, et al.
Published: (2018-12-01)

Ginsenoside Compound K Attenuates Ox-LDL-Mediated Macrophage Inflammation and Foam Cell Formation via Autophagy Induction and Modulating NF-κB, p38, and JNK MAPK Signaling
by: Shan Lu, et al.
Published: (2020-09-01)

Total Saponins of Aralia Elata (Miq) Seem Alleviate Calcium Homeostasis Imbalance and Endoplasmic Reticulum Stress-Related Apoptosis Induced by Myocardial Ischemia/Reperfusion Injury
by: Ruiying Wang, et al.
Published: (2018-10-01)

Targeting Orphan Nuclear Receptors NR4As for Energy Homeostasis and Diabetes
by: Chenyang Zhang, et al.
Published: (2020-11-01)

Network Pharmacology-Based Approach Uncovers the Mechanism of GuanXinNing Tablet for Treating Thrombus by MAPKs Signal Pathway
by: Mu-Lan Wang, et al.
Published: (2020-05-01)

Ginsenoside F1 Ameliorates Endothelial Cell Inflammatory Injury and Prevents Atherosclerosis in Mice through A20-Mediated Suppression of NF-kB Signaling
by: Meng Qin, et al.
Published: (2017-12-01)

Guanxinning Injection Combined With Ischemic Postconditioning Attenuate Myocardial Ischemic Reperfusion Injury in Chronic Renal Failure Rats by Modulating Mitochondrial Dynamics
by: Anzhu Wang, et al.
Published: (2022-05-01)

HMGB1-triggered inflammation inhibition of notoginseng leaf triterpenes against cerebral ischemia and reperfusion injury via MAPK and NF-κB signaling pathways
by: Weijie Xie, et al.
Published: (2019-09-01)

Efficacy observation of danshen injection iontophoresis treatment for vitreous hemorrhage
by: Jing Hao, et al.
Published: (2013-11-01)

Notoginsenoside R1 Protects db/db Mice against Diabetic Nephropathy via Upregulation of Nrf2-Mediated HO-1 Expression
by: Bin Zhang, et al.
Published: (2019-01-01)

Guanxin Salvia Miltiorrhiza Preparation protects rat cardiomyocytes against ischemia/reperfusion injury through miR-330-3p/ALDH2
by: YUAN Fang, et al.
Published: (2021-07-01)

Notoginsenoside R1 Improves Cerebral Ischemia/Reperfusion Injury by Promoting Neurogenesis via the BDNF/Akt/CREB Pathway
by: Ting Zhu, et al.
Published: (2021-05-01)

Correction: Meng, X., et al. Neuroprotective Effects of Radix Scrophulariae on Cerebral Ischemia and Reperfusion Injury via MAPK Pathways. Molecules 2018, 23, 2401
by: Xiangbao Meng, et al.
Published: (2018-10-01)

Cellular Immune Signal Exchange From Ischemic Stroke to Intestinal Lesions Through Brain-Gut Axis
by: Zizhao Yang, et al.
Published: (2022-04-01)

Effects of Platycodin D on Proliferation, Apoptosis and PI3K/Akt Signal Pathway of Human Glioma U251 Cells
by: Chong Xu, et al.
Published: (2014-12-01)

Araloside C Prevents Hypoxia/Reoxygenation-Induced Endoplasmic Reticulum Stress via Increasing Heat Shock Protein 90 in H9c2 Cardiomyocytes
by: Yuyang Du, et al.
Published: (2018-04-01)

Cryptoporus volvatus extract inhibits influenza virus replication in vitro and in vivo.
by: Li Gao, et al.
Published: (2014-01-01)

Compound Danshen Dripping Pills pretreatment protects the heart from ischemia/reperfusion injury by enhancing autophagic flux
by: Haiqiong Liu, et al.
Published: (2023-09-01)

Salvianolic Acid B and Ginsenoside Re Synergistically Protect Against Ox-LDL-Induced Endothelial Apoptosis Through the Antioxidative and Antiinflammatory Mechanisms
by: Ke Yang, et al.
Published: (2018-06-01)

Hydroxysafflor Yellow A Protects Against Myocardial Ischemia/Reperfusion Injury via Suppressing NLRP3 Inflammasome and Activating Autophagy
by: Jingxue Ye, et al.
Published: (2020-07-01)

Corrigendum: Hydroxysafflor Yellow A Protects Against Myocardial Ischemia/Reperfusion Injury via Suppressing NLRP3 Inflammasome and Activating Autophagy
by: Jingxue Ye, et al.
Published: (2021-04-01)

Gastrodin Ameliorates Cognitive Dysfunction in Diabetes Rat Model via the Suppression of Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation
by: Tianyuan Ye, et al.
Published: (2018-11-01)

Inhibitory Effects of Ginsenoside Rb1 on Early Atherosclerosis in ApoE-/- Mice via Inhibition of Apoptosis and Enhancing Autophagy
by: Ping Zhou, et al.
Published: (2018-11-01)

Protocol for rheumatoid arthritis complicated with cardiovascular damage treated with Guanxining tablet with a randomized controlled trial
by: Kai Yu, et al.
Published: (2023-09-01)

Panax notoginseng Saponin Protects Against Diabetic Cardiomyopathy Through Lipid Metabolism Modulation
by: Chenyang Zhang, et al.
Published: (2022-02-01)

Ginsenoside compound K protects human umbilical vein endothelial cells against oxidized low-density lipoprotein-induced injury via inhibition of nuclear factor-κB, p38, and JNK MAPK pathways
by: Shan Lu, et al.
Published: (2019-01-01)

Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice
by: Yadong Zhai, et al.
Published: (2018-02-01)

A Computational Toxicology Approach to Screen the Hepatotoxic Ingredients in Traditional Chinese Medicines: <i>Polygonum multiflorum</i> Thunb as a Case Study
by: Shuaibing He, et al.
Published: (2019-10-01)

Ginsenoside Rb1 as an Anti-Diabetic Agent and Its Underlying Mechanism Analysis
by: Ping Zhou, et al.
Published: (2019-02-01)

Bavachinin Induces Oxidative Damage in HepaRG Cells through p38/JNK MAPK Pathways
by: Shan Wang, et al.
Published: (2018-04-01)

The cardioprotective effect of danshen and gegen decoction on rat hearts and cardiomyocytes with post-ischemia reperfusion injury
by: Hu Fan, et al.
Published: (2012-12-01)

Attenuation of TNF-α-Induced Inflammatory Injury in Endothelial Cells by Ginsenoside Rb1 via Inhibiting NF-κB, JNK and p38 Signaling Pathways
by: Ping Zhou, et al.
Published: (2017-08-01)