Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism

Abstract Peroxisomes play a central role in tuning metabolic and signaling programs in a tissue- and cell-type-specific manner. However, the mechanisms by which the status of peroxisomes is communicated and integrated into cellular signaling pathways are not yet understood. Herein, we report the cel...

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Bibliographic Details
Main Authors: Akihiro Yamashita, Olesia Ignatenko, Mai Nguyen, Raphaëlle Lambert, Kathleen Watt, Caroline Daneault, Isabelle Robillard-Frayne, Ivan Topisirovic, Christine Des Rosiers, Heidi M. McBride
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Biology Direct
Online Access:https://doi.org/10.1186/s13062-023-00416-3