Microfibrillar‐associated protein 4 in serum is associated with asthma in Danish adolescents and young adults
Abstract Background Microfibrillar‐associated protein 4 (MFAP4) is an extracellular matrix protein belonging to the fibrinogen‐related protein superfamily, which plays multifaceted roles in innate immunity and normal endothelial function. It has been proposed that MFAP4 promotes the development of a...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-09-01
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| Series: | Immunity, Inflammation and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iid3.254 |
| _version_ | 1818517023509970944 |
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| author | Benjamin Hoffmann‐Petersen Raymond Suffolk Jens Jakob Herrche Petersen Thomas Houmann Petersen Kirsten Arendt Arne Høst Susanne Halken Grith Lykke Sorensen Lone Agertoft |
| author_facet | Benjamin Hoffmann‐Petersen Raymond Suffolk Jens Jakob Herrche Petersen Thomas Houmann Petersen Kirsten Arendt Arne Høst Susanne Halken Grith Lykke Sorensen Lone Agertoft |
| author_sort | Benjamin Hoffmann‐Petersen |
| collection | DOAJ |
| description | Abstract Background Microfibrillar‐associated protein 4 (MFAP4) is an extracellular matrix protein belonging to the fibrinogen‐related protein superfamily, which plays multifaceted roles in innate immunity and normal endothelial function. It has been proposed that MFAP4 promotes the development of asthma in vivo and proasthmatic pathways of bronchial smooth muscle cells in vitro. The aim of this study was to investigate the significance of serum MFAP4 in adolescents and young adolescents with persistent asthma. Methods Prospective, observational study including adolescents and young adults (age 11‐27 years) previously diagnosed with asthma during childhood 2003 to 2005 (0‐15 years) at the four pediatric outpatient clinics in the Region of Southern Denmark (n = 449). Healthy controls were recruited at follow‐up (n = 314). Detection of serum MFAP4 was performed by AlphaLISA technique. Results Current asthma was associated to a 14% higher mean level of serum MFAP4 compared with controls (expβ 1.14, 95% confidence intervals [CI], 1.05‐1.23) and a 6% higher mean level compared with subjects with no current asthma (expβ 1.06, 95% CI, 0.99‐1.13). No association was found at follow‐up between serum MFAP4 and self‐reported atopic symptoms (other than asthma), Asthma Control Test‐score, fractional exhaled nitric oxide (FeNO), nor to flow rate at 1 second, forced vital capacity, and forced expiratory flow 25% to 75%, response to short‐acting beta 2 agonist or mannitol. Conclusions We found a significantly higher mean level of serum MFAP4 in adolescent and young adults with mild to moderate asthma compared with healthy controls but no association to FeNO and lung function nor to the response to short‐acting beta 2 agonist or mannitol. The result supports the hypothesis that MFAP4 plays a role in the pathogenesis of asthma although the marker did not demonstrate any obvious potential as an asthma biomarker in adolescents and young adults with asthma. To understand the possible proasthmatic functions of MFAP4, further investigation in specific asthma phenotypes and the underlying molecular mechanisms is warranted. |
| first_indexed | 2024-12-11T00:50:23Z |
| format | Article |
| id | doaj.art-be38a67cc6ff48ef9ce4f2496e845c96 |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2024-12-11T00:50:23Z |
| publishDate | 2019-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-be38a67cc6ff48ef9ce4f2496e845c962022-12-22T01:26:38ZengWileyImmunity, Inflammation and Disease2050-45272019-09-017315015910.1002/iid3.254Microfibrillar‐associated protein 4 in serum is associated with asthma in Danish adolescents and young adultsBenjamin Hoffmann‐Petersen0Raymond Suffolk1Jens Jakob Herrche Petersen2Thomas Houmann Petersen3Kirsten Arendt4Arne Høst5Susanne Halken6Grith Lykke Sorensen7Lone Agertoft8Hans Christian Andersen Children's Hospital Odense University Hospital Odense DenmarkDepartment of Pediatrics Hospital of Southern Jutland Aabenraa DenmarkDepartment of Pediatrics Hospital of Southern Jutland Esbjerg DenmarkDepartment of Pediatrics Hospital of Southern Jutland Kolding DenmarkDepartment of Pediatrics Hospital of Southern Jutland Aabenraa DenmarkHans Christian Andersen Children's Hospital Odense University Hospital Odense DenmarkHans Christian Andersen Children's Hospital Odense University Hospital Odense DenmarkInstitute of Molecular Medicine University of Southern Denmark Odense DenmarkHans Christian Andersen Children's Hospital Odense University Hospital Odense DenmarkAbstract Background Microfibrillar‐associated protein 4 (MFAP4) is an extracellular matrix protein belonging to the fibrinogen‐related protein superfamily, which plays multifaceted roles in innate immunity and normal endothelial function. It has been proposed that MFAP4 promotes the development of asthma in vivo and proasthmatic pathways of bronchial smooth muscle cells in vitro. The aim of this study was to investigate the significance of serum MFAP4 in adolescents and young adolescents with persistent asthma. Methods Prospective, observational study including adolescents and young adults (age 11‐27 years) previously diagnosed with asthma during childhood 2003 to 2005 (0‐15 years) at the four pediatric outpatient clinics in the Region of Southern Denmark (n = 449). Healthy controls were recruited at follow‐up (n = 314). Detection of serum MFAP4 was performed by AlphaLISA technique. Results Current asthma was associated to a 14% higher mean level of serum MFAP4 compared with controls (expβ 1.14, 95% confidence intervals [CI], 1.05‐1.23) and a 6% higher mean level compared with subjects with no current asthma (expβ 1.06, 95% CI, 0.99‐1.13). No association was found at follow‐up between serum MFAP4 and self‐reported atopic symptoms (other than asthma), Asthma Control Test‐score, fractional exhaled nitric oxide (FeNO), nor to flow rate at 1 second, forced vital capacity, and forced expiratory flow 25% to 75%, response to short‐acting beta 2 agonist or mannitol. Conclusions We found a significantly higher mean level of serum MFAP4 in adolescent and young adults with mild to moderate asthma compared with healthy controls but no association to FeNO and lung function nor to the response to short‐acting beta 2 agonist or mannitol. The result supports the hypothesis that MFAP4 plays a role in the pathogenesis of asthma although the marker did not demonstrate any obvious potential as an asthma biomarker in adolescents and young adults with asthma. To understand the possible proasthmatic functions of MFAP4, further investigation in specific asthma phenotypes and the underlying molecular mechanisms is warranted.https://doi.org/10.1002/iid3.254adolescentasthmabiomarkerschildmicrofibrillar‐associated protein 4 |
| spellingShingle | Benjamin Hoffmann‐Petersen Raymond Suffolk Jens Jakob Herrche Petersen Thomas Houmann Petersen Kirsten Arendt Arne Høst Susanne Halken Grith Lykke Sorensen Lone Agertoft Microfibrillar‐associated protein 4 in serum is associated with asthma in Danish adolescents and young adults Immunity, Inflammation and Disease adolescent asthma biomarkers child microfibrillar‐associated protein 4 |
| title | Microfibrillar‐associated protein 4 in serum is associated with asthma in Danish adolescents and young adults |
| title_full | Microfibrillar‐associated protein 4 in serum is associated with asthma in Danish adolescents and young adults |
| title_fullStr | Microfibrillar‐associated protein 4 in serum is associated with asthma in Danish adolescents and young adults |
| title_full_unstemmed | Microfibrillar‐associated protein 4 in serum is associated with asthma in Danish adolescents and young adults |
| title_short | Microfibrillar‐associated protein 4 in serum is associated with asthma in Danish adolescents and young adults |
| title_sort | microfibrillar associated protein 4 in serum is associated with asthma in danish adolescents and young adults |
| topic | adolescent asthma biomarkers child microfibrillar‐associated protein 4 |
| url | https://doi.org/10.1002/iid3.254 |
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