Fetal neural stem cells from a mouse model of 15q11-13 duplication syndrome exhibit altered differentiation into neurons and astrocytes
The duplication of human chromosome 15q11-13 is known to be associated with an estimated 1.1% of autism cases. Here, we investigated whether differentiation into neurons and astrocytes is altered in fetal neural stem cells (FNSCs) isolated from the mouse model of 15q11-13 duplication syndrome (patDp...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-03-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861318302305 |
| _version_ | 1818601533397270528 |
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| author | Yunjung Choi Hyunju Kim Moonseok Choi Eun-Jeong Yang Toru Takumi Hye-Sun Kim |
| author_facet | Yunjung Choi Hyunju Kim Moonseok Choi Eun-Jeong Yang Toru Takumi Hye-Sun Kim |
| author_sort | Yunjung Choi |
| collection | DOAJ |
| description | The duplication of human chromosome 15q11-13 is known to be associated with an estimated 1.1% of autism cases. Here, we investigated whether differentiation into neurons and astrocytes is altered in fetal neural stem cells (FNSCs) isolated from the mouse model of 15q11-13 duplication syndrome (patDp/+ mice). In patDp/+ mice-derived FNSCs, multipotency was maintained for a longer period, the population of neurons was downregulated, and that of astrocytes was upregulated significantly after differentiation induction. These results suggest that the dysregulation of FNSCs differentiation could affect cortical development and behavioral deficits in the early postnatal stage shown in the patDp/+ mice. Keywords: Autism spectrum disorder, Paternal 15q11-13 duplication, FNSCs differentiation |
| first_indexed | 2024-12-16T12:52:54Z |
| format | Article |
| id | doaj.art-be395786928945f5a82069f4c412de67 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-16T12:52:54Z |
| publishDate | 2019-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-be395786928945f5a82069f4c412de672022-12-21T22:31:06ZengElsevierJournal of Pharmacological Sciences1347-86132019-03-011393249253Fetal neural stem cells from a mouse model of 15q11-13 duplication syndrome exhibit altered differentiation into neurons and astrocytesYunjung Choi0Hyunju Kim1Moonseok Choi2Eun-Jeong Yang3Toru Takumi4Hye-Sun Kim5Department of Pharmacology, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea; Department of Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of KoreaDepartment of Pharmacology, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea; Department of Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of KoreaDepartment of Pharmacology, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea; Department of Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of KoreaDepartment of Pharmacology, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea; Department of Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of KoreaRIKEN Brain Science Institute, Wako, Saitama, 351-0198, JapanDepartment of Pharmacology, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea; Department of Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea; Seoul National University Bundang Hospital, Seongnam, 463-707, South Korea; Neuroscience Research Institute, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea; Corresponding author. Department of Pharmacology, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea. Fax: +82 2 741 8298.The duplication of human chromosome 15q11-13 is known to be associated with an estimated 1.1% of autism cases. Here, we investigated whether differentiation into neurons and astrocytes is altered in fetal neural stem cells (FNSCs) isolated from the mouse model of 15q11-13 duplication syndrome (patDp/+ mice). In patDp/+ mice-derived FNSCs, multipotency was maintained for a longer period, the population of neurons was downregulated, and that of astrocytes was upregulated significantly after differentiation induction. These results suggest that the dysregulation of FNSCs differentiation could affect cortical development and behavioral deficits in the early postnatal stage shown in the patDp/+ mice. Keywords: Autism spectrum disorder, Paternal 15q11-13 duplication, FNSCs differentiationhttp://www.sciencedirect.com/science/article/pii/S1347861318302305 |
| spellingShingle | Yunjung Choi Hyunju Kim Moonseok Choi Eun-Jeong Yang Toru Takumi Hye-Sun Kim Fetal neural stem cells from a mouse model of 15q11-13 duplication syndrome exhibit altered differentiation into neurons and astrocytes Journal of Pharmacological Sciences |
| title | Fetal neural stem cells from a mouse model of 15q11-13 duplication syndrome exhibit altered differentiation into neurons and astrocytes |
| title_full | Fetal neural stem cells from a mouse model of 15q11-13 duplication syndrome exhibit altered differentiation into neurons and astrocytes |
| title_fullStr | Fetal neural stem cells from a mouse model of 15q11-13 duplication syndrome exhibit altered differentiation into neurons and astrocytes |
| title_full_unstemmed | Fetal neural stem cells from a mouse model of 15q11-13 duplication syndrome exhibit altered differentiation into neurons and astrocytes |
| title_short | Fetal neural stem cells from a mouse model of 15q11-13 duplication syndrome exhibit altered differentiation into neurons and astrocytes |
| title_sort | fetal neural stem cells from a mouse model of 15q11 13 duplication syndrome exhibit altered differentiation into neurons and astrocytes |
| url | http://www.sciencedirect.com/science/article/pii/S1347861318302305 |
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