A Review of Priapism Associated with Quetiapine
Priapism is defined as the painful and prolonged penile erection in the absence of any sexual desire and arousal. It is considered as a urologic emergency and needs immediate attention as it can lead to sexual dysfunction. It has various etiologies, including idiopathic, medicinal, and medical ones....
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2019-03-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-11954-en.html |
| _version_ | 1828054964622065664 |
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| author | Davood Hosseini Talari Arghavan Fariborzifar Ali Issapour Hamzeh Hosseini |
| author_facet | Davood Hosseini Talari Arghavan Fariborzifar Ali Issapour Hamzeh Hosseini |
| author_sort | Davood Hosseini Talari |
| collection | DOAJ |
| description | Priapism is defined as the painful and prolonged penile erection in the absence of any sexual desire and arousal. It is considered as a urologic emergency and needs immediate attention as it can lead to sexual dysfunction. It has various etiologies, including idiopathic, medicinal, and medical ones. It is divided into two types: low-flow and high-flow. Medications, including quetiapine cause low-flow priapism. The aim of this study was to review the relationship between quetiapine use and priapism.
In most reports of drug-induced priapism, there was no relationship between the dose and duration of drug use. But a relationship was found between quetiapine use and priapism, due to overdose, continuous or single dose, and idiosyncratic reaction. Other than quetiapine, some other antipsychotics could also cause periapism. Recurrent priapism could happen in people with history of drug-induced priapism if the dug is continued. Priapism is associated with the mechanism of alpha1 adrenergic receptor blocking in the penis corpus cavernosum. The antipsychotics affinity to blocking this receptor are different and in quetiapine there is a moderate tendency. Co-administration of CYP450 inhibitors with quetiapine increases some complications such as priapism, and vice versa the inducers of these enzymes, such as smoking, alongside quetiapine decrease this complication by reducing serum levels of the drug. Awareness about the possibility of complications of quetiapine by physicians lead to prompt diagnosis and treatment, thereby preventing other associated complications. |
| first_indexed | 2024-04-10T20:31:05Z |
| format | Article |
| id | doaj.art-be3a5bf3ef4047e8ad420dacd87dbecb |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:31:05Z |
| publishDate | 2019-03-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-be3a5bf3ef4047e8ad420dacd87dbecb2023-01-25T06:58:28ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792019-03-0128170200210A Review of Priapism Associated with QuetiapineDavood Hosseini Talari0Arghavan Fariborzifar1Ali Issapour2Hamzeh Hosseini3 Psychosomatic Medicine Fellowship, Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Resident in Psychiatry, Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Assistant Professor, Department of Urology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Professor, Department of Psychiatry, Psychiatry and Behavioral Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran Priapism is defined as the painful and prolonged penile erection in the absence of any sexual desire and arousal. It is considered as a urologic emergency and needs immediate attention as it can lead to sexual dysfunction. It has various etiologies, including idiopathic, medicinal, and medical ones. It is divided into two types: low-flow and high-flow. Medications, including quetiapine cause low-flow priapism. The aim of this study was to review the relationship between quetiapine use and priapism. In most reports of drug-induced priapism, there was no relationship between the dose and duration of drug use. But a relationship was found between quetiapine use and priapism, due to overdose, continuous or single dose, and idiosyncratic reaction. Other than quetiapine, some other antipsychotics could also cause periapism. Recurrent priapism could happen in people with history of drug-induced priapism if the dug is continued. Priapism is associated with the mechanism of alpha1 adrenergic receptor blocking in the penis corpus cavernosum. The antipsychotics affinity to blocking this receptor are different and in quetiapine there is a moderate tendency. Co-administration of CYP450 inhibitors with quetiapine increases some complications such as priapism, and vice versa the inducers of these enzymes, such as smoking, alongside quetiapine decrease this complication by reducing serum levels of the drug. Awareness about the possibility of complications of quetiapine by physicians lead to prompt diagnosis and treatment, thereby preventing other associated complications.http://jmums.mazums.ac.ir/article-1-11954-en.htmlpriapismantipsychoticsquetiapine |
| spellingShingle | Davood Hosseini Talari Arghavan Fariborzifar Ali Issapour Hamzeh Hosseini A Review of Priapism Associated with Quetiapine Journal of Mazandaran University of Medical Sciences priapism antipsychotics quetiapine |
| title | A Review of Priapism Associated with Quetiapine |
| title_full | A Review of Priapism Associated with Quetiapine |
| title_fullStr | A Review of Priapism Associated with Quetiapine |
| title_full_unstemmed | A Review of Priapism Associated with Quetiapine |
| title_short | A Review of Priapism Associated with Quetiapine |
| title_sort | review of priapism associated with quetiapine |
| topic | priapism antipsychotics quetiapine |
| url | http://jmums.mazums.ac.ir/article-1-11954-en.html |
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