Bioorthogonal Chemistry Approach for the Theranostics of GRPR-Expressing Cancers

Bioorthogonal Chemistry Approach for the Theranostics of GRPR-Expressing Cancers

Several gastrin-releasing peptide receptor (GRPR) antagonists with improved in vivo behavior have been recently developed and tested in the clinic. However, despite the generally mild side effects of peptide receptor radionuclide therapy (PRRT), toxicity has been observed due to high doses delivered...

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Bibliographic Details
Main Authors: Alice D’Onofrio, Francisco Silva, Lurdes Gano, Paula Raposinho, Célia Fernandes, Arkadiusz Sikora, Monika Wyczółkowska, Renata Mikołajczak, Piotr Garnuszek, António Paulo
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pharmaceutics
Subjects:
click chemistry
GRPR antagonist
theranostics
tetrazine
PRRT
Online Access:https://www.mdpi.com/1999-4923/14/12/2569

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