Retrospective analysis of primary intraosseous malignancies in mandible and maxilla in a population of Taiwanese patients
Background/Purpose: Due to the rarity and diversity of primary intraosseous malignancies in jawbones, we aimed to evaluate the clinicopathological features and discuss the findings of our collected cases with the literatures. Methods: Twenty-nine patients (2000–2020) diagnosed with primary central m...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Jezik: | English |
| Izdano: |
Elsevier
2022-04-01
|
| Serija: | Journal of the Formosan Medical Association |
| Teme: | |
| Online dostop: | http://www.sciencedirect.com/science/article/pii/S0929664621004009 |
| _version_ | 1828855088886579200 |
|---|---|
| author | Chih-Huang Tseng Wen-Chen Wang Ching-Yi Chen Han-Jen Hsu Yuk-Kwan Chen |
| author_facet | Chih-Huang Tseng Wen-Chen Wang Ching-Yi Chen Han-Jen Hsu Yuk-Kwan Chen |
| author_sort | Chih-Huang Tseng |
| collection | DOAJ |
| description | Background/Purpose: Due to the rarity and diversity of primary intraosseous malignancies in jawbones, we aimed to evaluate the clinicopathological features and discuss the findings of our collected cases with the literatures. Methods: Twenty-nine patients (2000–2020) diagnosed with primary central malignancies of jawbones were selected from the database of Oral Pathology Department in our institution. Clinical features, radiographic appearance, and histopathological diagnosis of the 29 cases were analyzed. Results: Twenty-nine patients aged between 19 and 84 years (average, 57.4 years) with a male to female ratio of 1.2:1 were included. The most frequent site was the mandibular body and ramus, followed by the posterior maxilla and mandibular symphysis. The most common diagnosis was osteogenic sarcoma (n = 13), followed by odontogenic carcinoma (n = 7), hematologic malignancies (n = 5), salivary gland malignancies (n = 2), and neurogenic sarcomas (n = 2). The most frequent symptoms were swelling, pain, paresthesia of lower lip, and mobile tooth. Radiographically, they usually presented as ill-defined osteolytic to osteoblastic lesions depending on the amount of ossification. Wide excision comprising partial maxillectomy and segmental mandibulectomy were the most common therapeutic methods. Conclusion: Despite the rarity of primary central malignancies in jawbones, the clinical features may mimic infectious process or benign lesions. Detailed history-taking, clinical and imaging examination and awareness of the patient's signs and symptoms combining with the histopathological inspection are important for early diagnosis and improved prognosis. The current data contributes a useful basis for clinical investigation regarding intraosseous malignancies occurring in the jawbones. |
| first_indexed | 2024-12-13T00:48:05Z |
| format | Article |
| id | doaj.art-be3a88f0a41b4ef7b8d75bd954b19b64 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-13T00:48:05Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-be3a88f0a41b4ef7b8d75bd954b19b642022-12-22T00:04:59ZengElsevierJournal of the Formosan Medical Association0929-66462022-04-011214787795Retrospective analysis of primary intraosseous malignancies in mandible and maxilla in a population of Taiwanese patientsChih-Huang Tseng0Wen-Chen Wang1Ching-Yi Chen2Han-Jen Hsu3Yuk-Kwan Chen4Division of Oral Pathology & Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Oral & Maxillofacial Imaging Center, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Oral Pathology & Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Oral & Maxillofacial Imaging Center, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Oral Pathology & Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Oral & Maxillofacial Imaging Center, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Oral & Maxillofacial Surgery, Kaohsiung Medical University Hospital Kaohsiung, TaiwanDivision of Oral Pathology & Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Oral & Maxillofacial Imaging Center, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Corresponding author. School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 807, Taiwan. Fax: +886 7 3210537.Background/Purpose: Due to the rarity and diversity of primary intraosseous malignancies in jawbones, we aimed to evaluate the clinicopathological features and discuss the findings of our collected cases with the literatures. Methods: Twenty-nine patients (2000–2020) diagnosed with primary central malignancies of jawbones were selected from the database of Oral Pathology Department in our institution. Clinical features, radiographic appearance, and histopathological diagnosis of the 29 cases were analyzed. Results: Twenty-nine patients aged between 19 and 84 years (average, 57.4 years) with a male to female ratio of 1.2:1 were included. The most frequent site was the mandibular body and ramus, followed by the posterior maxilla and mandibular symphysis. The most common diagnosis was osteogenic sarcoma (n = 13), followed by odontogenic carcinoma (n = 7), hematologic malignancies (n = 5), salivary gland malignancies (n = 2), and neurogenic sarcomas (n = 2). The most frequent symptoms were swelling, pain, paresthesia of lower lip, and mobile tooth. Radiographically, they usually presented as ill-defined osteolytic to osteoblastic lesions depending on the amount of ossification. Wide excision comprising partial maxillectomy and segmental mandibulectomy were the most common therapeutic methods. Conclusion: Despite the rarity of primary central malignancies in jawbones, the clinical features may mimic infectious process or benign lesions. Detailed history-taking, clinical and imaging examination and awareness of the patient's signs and symptoms combining with the histopathological inspection are important for early diagnosis and improved prognosis. The current data contributes a useful basis for clinical investigation regarding intraosseous malignancies occurring in the jawbones.http://www.sciencedirect.com/science/article/pii/S0929664621004009Clinical manifestationIntraosseousJawboneMalignancyTaiwan |
| spellingShingle | Chih-Huang Tseng Wen-Chen Wang Ching-Yi Chen Han-Jen Hsu Yuk-Kwan Chen Retrospective analysis of primary intraosseous malignancies in mandible and maxilla in a population of Taiwanese patients Journal of the Formosan Medical Association Clinical manifestation Intraosseous Jawbone Malignancy Taiwan |
| title | Retrospective analysis of primary intraosseous malignancies in mandible and maxilla in a population of Taiwanese patients |
| title_full | Retrospective analysis of primary intraosseous malignancies in mandible and maxilla in a population of Taiwanese patients |
| title_fullStr | Retrospective analysis of primary intraosseous malignancies in mandible and maxilla in a population of Taiwanese patients |
| title_full_unstemmed | Retrospective analysis of primary intraosseous malignancies in mandible and maxilla in a population of Taiwanese patients |
| title_short | Retrospective analysis of primary intraosseous malignancies in mandible and maxilla in a population of Taiwanese patients |
| title_sort | retrospective analysis of primary intraosseous malignancies in mandible and maxilla in a population of taiwanese patients |
| topic | Clinical manifestation Intraosseous Jawbone Malignancy Taiwan |
| url | http://www.sciencedirect.com/science/article/pii/S0929664621004009 |
| work_keys_str_mv | AT chihhuangtseng retrospectiveanalysisofprimaryintraosseousmalignanciesinmandibleandmaxillainapopulationoftaiwanesepatients AT wenchenwang retrospectiveanalysisofprimaryintraosseousmalignanciesinmandibleandmaxillainapopulationoftaiwanesepatients AT chingyichen retrospectiveanalysisofprimaryintraosseousmalignanciesinmandibleandmaxillainapopulationoftaiwanesepatients AT hanjenhsu retrospectiveanalysisofprimaryintraosseousmalignanciesinmandibleandmaxillainapopulationoftaiwanesepatients AT yukkwanchen retrospectiveanalysisofprimaryintraosseousmalignanciesinmandibleandmaxillainapopulationoftaiwanesepatients |