Binding of prorenin to (pro)renin receptor induces the proliferation of human umbilical artery smooth muscle cells via ROS generation and ERK1/2 activation

Binding of prorenin to (pro)renin receptor induces the proliferation of human umbilical artery smooth muscle cells via ROS generation and ERK1/2 activation

Introduction: Since the discovery of the (pro)renin receptor (PRR), it has been considered as a novel bioactive molecule of the renin–angiotensin system (RAS). The activation of PRR can elicit a series of angiotensin II (AngII)-independent effects. Materials and methods: In this study, we investigat...

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Bibliographic Details
Main Authors: Feng Y Liu, Xiao Y Liu, Li J Zhang, Yun P Cheng, Yi N Jiang
Format: Article
Language:English
Published: SAGE Publications 2014-06-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.1177/1470320314525215

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