Protective effect of Rheum ribes extract against lead-induced hepatotoxicity in male rats
Abstract The effects of Rheum ribes on lead acetate levels and hepatic biochemical factors due to lead acetate toxicity were investigated. Forty male Wistar rats were designated into four groups: Control; lead acetate (receiving in drinking water at 0.6 g/L, daily); hydroalcoholic extract groups (20...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidade de São Paulo
2023-01-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100312&tlng=en |
| _version_ | 1797951334804094976 |
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| author | Shirin Asgharian Zahra Lorigooini Elham Bijad Hasan Hosseinkhani Zahra Abbasian Mahmoud Rafieian-Kopaei |
| author_facet | Shirin Asgharian Zahra Lorigooini Elham Bijad Hasan Hosseinkhani Zahra Abbasian Mahmoud Rafieian-Kopaei |
| author_sort | Shirin Asgharian |
| collection | DOAJ |
| description | Abstract The effects of Rheum ribes on lead acetate levels and hepatic biochemical factors due to lead acetate toxicity were investigated. Forty male Wistar rats were designated into four groups: Control; lead acetate (receiving in drinking water at 0.6 g/L, daily); hydroalcoholic extract groups (200 and 400 mg/kg doses, gavage, once daily). Treatments were conducted for 10 days. On the 11th day, blood samples were collected to measure lead acetate levels and biochemical factors. Liver tissue samples were examined for histopathological changes. Lead serum levels were increased in lead acetate-treated rats (p<0.001). Lead acetate treatment was associated with a significant increase in liver tissue damage (p<0.001), while R. ribes extract prevented liver tissue damage (p<0.05). The levels of alanine aminotransferase and aspartate aminotransferase were significantly lower in the groups lead acetate + extract (two doses) than in the lead acetate group (p<0.001 and P<0.01, respectively), but alkaline phosphatase level, prothrombin time, partial thromboplastin time and international normalized ratio were not different between the lead acetate + extract groups and the lead acetate group. The results showed the inhibitory role of R. ribes on lead-induced hepato-toxicity. The results make Rhubarb a good candidate to protect against the deleterious effect of chronic lead intoxication after complementary studies. |
| first_indexed | 2024-04-10T22:28:56Z |
| format | Article |
| id | doaj.art-be40786fcad44224a6e8b7e1b7204e30 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-10T22:28:56Z |
| publishDate | 2023-01-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-be40786fcad44224a6e8b7e1b7204e302023-01-17T07:34:53ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902023-01-015810.1590/s2175-97902022e191127Protective effect of Rheum ribes extract against lead-induced hepatotoxicity in male ratsShirin AsgharianZahra LorigooiniElham BijadHasan HosseinkhaniZahra AbbasianMahmoud Rafieian-Kopaeihttps://orcid.org/0000-0002-1860-1141Abstract The effects of Rheum ribes on lead acetate levels and hepatic biochemical factors due to lead acetate toxicity were investigated. Forty male Wistar rats were designated into four groups: Control; lead acetate (receiving in drinking water at 0.6 g/L, daily); hydroalcoholic extract groups (200 and 400 mg/kg doses, gavage, once daily). Treatments were conducted for 10 days. On the 11th day, blood samples were collected to measure lead acetate levels and biochemical factors. Liver tissue samples were examined for histopathological changes. Lead serum levels were increased in lead acetate-treated rats (p<0.001). Lead acetate treatment was associated with a significant increase in liver tissue damage (p<0.001), while R. ribes extract prevented liver tissue damage (p<0.05). The levels of alanine aminotransferase and aspartate aminotransferase were significantly lower in the groups lead acetate + extract (two doses) than in the lead acetate group (p<0.001 and P<0.01, respectively), but alkaline phosphatase level, prothrombin time, partial thromboplastin time and international normalized ratio were not different between the lead acetate + extract groups and the lead acetate group. The results showed the inhibitory role of R. ribes on lead-induced hepato-toxicity. The results make Rhubarb a good candidate to protect against the deleterious effect of chronic lead intoxication after complementary studies.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100312&tlng=enHepatotoxicityLead acetateRatRheum ribes L |
| spellingShingle | Shirin Asgharian Zahra Lorigooini Elham Bijad Hasan Hosseinkhani Zahra Abbasian Mahmoud Rafieian-Kopaei Protective effect of Rheum ribes extract against lead-induced hepatotoxicity in male rats Brazilian Journal of Pharmaceutical Sciences Hepatotoxicity Lead acetate Rat Rheum ribes L |
| title | Protective effect of Rheum ribes extract against lead-induced hepatotoxicity in male rats |
| title_full | Protective effect of Rheum ribes extract against lead-induced hepatotoxicity in male rats |
| title_fullStr | Protective effect of Rheum ribes extract against lead-induced hepatotoxicity in male rats |
| title_full_unstemmed | Protective effect of Rheum ribes extract against lead-induced hepatotoxicity in male rats |
| title_short | Protective effect of Rheum ribes extract against lead-induced hepatotoxicity in male rats |
| title_sort | protective effect of rheum ribes extract against lead induced hepatotoxicity in male rats |
| topic | Hepatotoxicity Lead acetate Rat Rheum ribes L |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100312&tlng=en |
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