Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells
Sequestering mRNA in cytoplasmic stress granules is a mechanism for translational repression. Here the authors find that p53 mRNA, present in stress granules in activated B lymphocytes, is released upon DNA damage and is translated in a CAP-independent manner.
| Main Authors: | , , , , , |
|---|---|
| פורמט: | Article |
| שפה: | English |
| יצא לאור: |
Nature Portfolio
2017-09-01
|
| סדרה: | Nature Communications |
| גישה מקוונת: | https://doi.org/10.1038/s41467-017-00454-2 |