Targeting protein glycosylation to regulate inflammation in the respiratory tract: novel diagnostic and therapeutic candidates for chronic respiratory diseases
Protein glycosylation is a widespread posttranslational modification that can impact the function of proteins. Dysregulated protein glycosylation has been linked to several diseases, including chronic respiratory diseases (CRDs). CRDs pose a significant public health threat globally, affecting the a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1168023/full |
| _version_ | 1827947446261514240 |
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| author | Xiaofeng Xie Siyuan Kong Weiqian Cao Weiqian Cao |
| author_facet | Xiaofeng Xie Siyuan Kong Weiqian Cao Weiqian Cao |
| author_sort | Xiaofeng Xie |
| collection | DOAJ |
| description | Protein glycosylation is a widespread posttranslational modification that can impact the function of proteins. Dysregulated protein glycosylation has been linked to several diseases, including chronic respiratory diseases (CRDs). CRDs pose a significant public health threat globally, affecting the airways and other lung structures. Emerging researches suggest that glycosylation plays a significant role in regulating inflammation associated with CRDs. This review offers an overview of the abnormal glycoenzyme activity and corresponding glycosylation changes involved in various CRDs, including chronic obstructive pulmonary disease, asthma, cystic fibrosis, idiopathic pulmonary fibrosis, pulmonary arterial hypertension, non-cystic fibrosis bronchiectasis, and lung cancer. Additionally, this review summarizes recent advances in glycomics and glycoproteomics-based protein glycosylation analysis of CRDs. The potential of glycoenzymes and glycoproteins for clinical use in the diagnosis and treatment of CRDs is also discussed. |
| first_indexed | 2024-04-09T12:39:03Z |
| format | Article |
| id | doaj.art-be41a32c03f1492388033584b13c965e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T12:39:03Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-be41a32c03f1492388033584b13c965e2023-05-15T04:34:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-05-011410.3389/fimmu.2023.11680231168023Targeting protein glycosylation to regulate inflammation in the respiratory tract: novel diagnostic and therapeutic candidates for chronic respiratory diseasesXiaofeng Xie0Siyuan Kong1Weiqian Cao2Weiqian Cao3Shanghai Fifth People’s Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, ChinaShanghai Fifth People’s Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, ChinaShanghai Fifth People’s Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, ChinaNHC Key Laboratory of Glycoconjugates Research, Fudan University, Shanghai, ChinaProtein glycosylation is a widespread posttranslational modification that can impact the function of proteins. Dysregulated protein glycosylation has been linked to several diseases, including chronic respiratory diseases (CRDs). CRDs pose a significant public health threat globally, affecting the airways and other lung structures. Emerging researches suggest that glycosylation plays a significant role in regulating inflammation associated with CRDs. This review offers an overview of the abnormal glycoenzyme activity and corresponding glycosylation changes involved in various CRDs, including chronic obstructive pulmonary disease, asthma, cystic fibrosis, idiopathic pulmonary fibrosis, pulmonary arterial hypertension, non-cystic fibrosis bronchiectasis, and lung cancer. Additionally, this review summarizes recent advances in glycomics and glycoproteomics-based protein glycosylation analysis of CRDs. The potential of glycoenzymes and glycoproteins for clinical use in the diagnosis and treatment of CRDs is also discussed.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1168023/fullprotein glycosylationchronic respiratory diseasesabnormal glycoenzyme activityglycoproteomicsglycobiomarkers |
| spellingShingle | Xiaofeng Xie Siyuan Kong Weiqian Cao Weiqian Cao Targeting protein glycosylation to regulate inflammation in the respiratory tract: novel diagnostic and therapeutic candidates for chronic respiratory diseases Frontiers in Immunology protein glycosylation chronic respiratory diseases abnormal glycoenzyme activity glycoproteomics glycobiomarkers |
| title | Targeting protein glycosylation to regulate inflammation in the respiratory tract: novel diagnostic and therapeutic candidates for chronic respiratory diseases |
| title_full | Targeting protein glycosylation to regulate inflammation in the respiratory tract: novel diagnostic and therapeutic candidates for chronic respiratory diseases |
| title_fullStr | Targeting protein glycosylation to regulate inflammation in the respiratory tract: novel diagnostic and therapeutic candidates for chronic respiratory diseases |
| title_full_unstemmed | Targeting protein glycosylation to regulate inflammation in the respiratory tract: novel diagnostic and therapeutic candidates for chronic respiratory diseases |
| title_short | Targeting protein glycosylation to regulate inflammation in the respiratory tract: novel diagnostic and therapeutic candidates for chronic respiratory diseases |
| title_sort | targeting protein glycosylation to regulate inflammation in the respiratory tract novel diagnostic and therapeutic candidates for chronic respiratory diseases |
| topic | protein glycosylation chronic respiratory diseases abnormal glycoenzyme activity glycoproteomics glycobiomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1168023/full |
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