Impact of COVID‐19 versus chronic rhinosinusitis/rhinitis associated olfactory dysfunction on health utility and quality of life
Abstract Background Olfactory dysfunction (OD) is associated with both post‐viral and inflammatory etiologies such as COVID‐19 and chronic rhinosinusitis/rhinitis (CRS/R) respectively, to result in reduced quality of life (QoL). However, the former typically induces a sudden‐onset OD while the latte...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-10-01
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| Series: | Laryngoscope Investigative Otolaryngology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/lio2.921 |
| _version_ | 1798031229068509184 |
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| author | Thanh Luong Sophie S. Jang Mena Said Adam S. DeConde Carol H. Yan |
| author_facet | Thanh Luong Sophie S. Jang Mena Said Adam S. DeConde Carol H. Yan |
| author_sort | Thanh Luong |
| collection | DOAJ |
| description | Abstract Background Olfactory dysfunction (OD) is associated with both post‐viral and inflammatory etiologies such as COVID‐19 and chronic rhinosinusitis/rhinitis (CRS/R) respectively, to result in reduced quality of life (QoL). However, the former typically induces a sudden‐onset OD while the latter has a gradual presentation. This study aims to establish and compare health utility values (HUVs) and olfactory‐specific QoL measurements between patients with COVID‐19 and CRS/R related OD. Methods This prospective study surveyed COVID‐19 and CRS/R patients with self‐reported OD using HUV assessments (EuroQol‐visual analog scale [EQ‐VAS], EuroQol‐5 dimension [EQ‐5D], time trade‐off [TTO]) and olfactory and sinonasal QoL measures (questionnaire of olfactory disorders –negative and positive statements [QOD‐NS + PS] and sino‐nasal outcome test [SNOT‐22]). A subgroup of subjects completed objective olfactory testing. Intergroup mean scores were compared using Mann–Whitney U tests. Results One hundred eleven subjects were enrolled: mean age ± SD (43.0 ± 15.4 years), 55.9% female. CRS/R was associated with lower HUVs as measured by EQ‐VAS (CRS/R: 0.67 ± 0.18 vs. COVID‐19: 0.74 ± 0.19, p = .03) and worse SNOT‐22 scores in both overall (CRS/R: 49.03 ± 21.04 vs. COVID‐19: 27.58 ± 18.45, p < .001) and subgroup analysis of objectively confirmed OD subjects (CRS/R: 52.40 ± 22.78 vs. COVID‐19: 29.84 ± 21.10, p = .01). On the other hand, COVID‐19 has greater burden on olfactory‐specific QoL (QOD‐NS + PS, COVID‐19: 23.19 ± 13.73 vs. CRS/R: 17.25 ± 11.38, p = .04). Both groups demonstrated a similar decrease in health using the EQ‐5D assessment. Conclusion CRS/R associated OD has a more severe impact on general health and sinonasal specific QoL outcomes, while COVID‐19 associated OD has a greater burden on olfactory‐specific QoL. Level of evidence Level 2c. |
| first_indexed | 2024-04-11T19:54:04Z |
| format | Article |
| id | doaj.art-be43a1326aed446ab01ccf7e8300680e |
| institution | Directory Open Access Journal |
| issn | 2378-8038 |
| language | English |
| last_indexed | 2024-04-11T19:54:04Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj.art-be43a1326aed446ab01ccf7e8300680e2022-12-22T04:06:13ZengWileyLaryngoscope Investigative Otolaryngology2378-80382022-10-01751299130710.1002/lio2.921Impact of COVID‐19 versus chronic rhinosinusitis/rhinitis associated olfactory dysfunction on health utility and quality of lifeThanh Luong0Sophie S. Jang1Mena Said2Adam S. DeConde3Carol H. Yan4Department of Otolaryngology – Head and Neck Surgery University of California San Diego San Diego California USADepartment of Otolaryngology – Head and Neck Surgery University of California San Diego San Diego California USADepartment of Otolaryngology – Head and Neck Surgery University of California San Diego San Diego California USADepartment of Otolaryngology – Head and Neck Surgery University of California San Diego San Diego California USADepartment of Otolaryngology – Head and Neck Surgery University of California San Diego San Diego California USAAbstract Background Olfactory dysfunction (OD) is associated with both post‐viral and inflammatory etiologies such as COVID‐19 and chronic rhinosinusitis/rhinitis (CRS/R) respectively, to result in reduced quality of life (QoL). However, the former typically induces a sudden‐onset OD while the latter has a gradual presentation. This study aims to establish and compare health utility values (HUVs) and olfactory‐specific QoL measurements between patients with COVID‐19 and CRS/R related OD. Methods This prospective study surveyed COVID‐19 and CRS/R patients with self‐reported OD using HUV assessments (EuroQol‐visual analog scale [EQ‐VAS], EuroQol‐5 dimension [EQ‐5D], time trade‐off [TTO]) and olfactory and sinonasal QoL measures (questionnaire of olfactory disorders –negative and positive statements [QOD‐NS + PS] and sino‐nasal outcome test [SNOT‐22]). A subgroup of subjects completed objective olfactory testing. Intergroup mean scores were compared using Mann–Whitney U tests. Results One hundred eleven subjects were enrolled: mean age ± SD (43.0 ± 15.4 years), 55.9% female. CRS/R was associated with lower HUVs as measured by EQ‐VAS (CRS/R: 0.67 ± 0.18 vs. COVID‐19: 0.74 ± 0.19, p = .03) and worse SNOT‐22 scores in both overall (CRS/R: 49.03 ± 21.04 vs. COVID‐19: 27.58 ± 18.45, p < .001) and subgroup analysis of objectively confirmed OD subjects (CRS/R: 52.40 ± 22.78 vs. COVID‐19: 29.84 ± 21.10, p = .01). On the other hand, COVID‐19 has greater burden on olfactory‐specific QoL (QOD‐NS + PS, COVID‐19: 23.19 ± 13.73 vs. CRS/R: 17.25 ± 11.38, p = .04). Both groups demonstrated a similar decrease in health using the EQ‐5D assessment. Conclusion CRS/R associated OD has a more severe impact on general health and sinonasal specific QoL outcomes, while COVID‐19 associated OD has a greater burden on olfactory‐specific QoL. Level of evidence Level 2c.https://doi.org/10.1002/lio2.921chronic rhinosinusitisCOVID‐19health utility valuesolfactory dysfunctionquality of life |
| spellingShingle | Thanh Luong Sophie S. Jang Mena Said Adam S. DeConde Carol H. Yan Impact of COVID‐19 versus chronic rhinosinusitis/rhinitis associated olfactory dysfunction on health utility and quality of life Laryngoscope Investigative Otolaryngology chronic rhinosinusitis COVID‐19 health utility values olfactory dysfunction quality of life |
| title | Impact of COVID‐19 versus chronic rhinosinusitis/rhinitis associated olfactory dysfunction on health utility and quality of life |
| title_full | Impact of COVID‐19 versus chronic rhinosinusitis/rhinitis associated olfactory dysfunction on health utility and quality of life |
| title_fullStr | Impact of COVID‐19 versus chronic rhinosinusitis/rhinitis associated olfactory dysfunction on health utility and quality of life |
| title_full_unstemmed | Impact of COVID‐19 versus chronic rhinosinusitis/rhinitis associated olfactory dysfunction on health utility and quality of life |
| title_short | Impact of COVID‐19 versus chronic rhinosinusitis/rhinitis associated olfactory dysfunction on health utility and quality of life |
| title_sort | impact of covid 19 versus chronic rhinosinusitis rhinitis associated olfactory dysfunction on health utility and quality of life |
| topic | chronic rhinosinusitis COVID‐19 health utility values olfactory dysfunction quality of life |
| url | https://doi.org/10.1002/lio2.921 |
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