Impact of ticagrelor on P2Y1 and P2Y12 localization and on cholesterol levels in platelet plasma membrane

Impact of ticagrelor on P2Y1 and P2Y12 localization and on cholesterol levels in platelet plasma membrane

Ticagrelor is an antiplatelet agent that inhibits platelet activation via P2Y12 antagonism. There are several studies showing that P2Y12 needs lipid rafts to be activated, but there are few data about how ticagrelor impacts lipid raft organization. Therefore, we aimed to investigate how ticagrelor c...

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Bibliographic Details
Main Authors: Vahideh Rabani, Damien Montange, Nicolas Meneveau, Siamak Davani
Format: Article
Language:English
Published: Taylor & Francis Group 2018-10-01
Series:Platelets
Subjects:
adp
cholesterol
lipid rafts
platelets
ticagrelor
Online Access:http://dx.doi.org/10.1080/09537104.2017.1356453

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