Efficacy of fermented grain using Bacillus coagulans in reducing visceral fat among people with obesity: a randomized controlled trial
BackgroundObesity is a socioeconomic problem, and visceral obesity, in particular, is related to cardiovascular diseases or metabolic syndrome. Fermented grains and various microorganisms are known to help with anti-obesity effects and weight management. Studies on the relationship between Bacillus...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1148512/full |
| _version_ | 1797845561058000896 |
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| author | Eunbyul Cho Ju Young Kim Belong Cho Joong Su Lee Yeo Cho Yoon Yong Chul Shin Hyerim Kim Siye Gil Sohye Kim |
| author_facet | Eunbyul Cho Ju Young Kim Belong Cho Joong Su Lee Yeo Cho Yoon Yong Chul Shin Hyerim Kim Siye Gil Sohye Kim |
| author_sort | Eunbyul Cho |
| collection | DOAJ |
| description | BackgroundObesity is a socioeconomic problem, and visceral obesity, in particular, is related to cardiovascular diseases or metabolic syndrome. Fermented grains and various microorganisms are known to help with anti-obesity effects and weight management. Studies on the relationship between Bacillus coagulans and anti-obesity effects are not well known, and studies on the application of fermented grains and microorganisms to the human body are also insufficient.ObjectivesThis study aimed to evaluate the efficacy of Curezyme–LAC, an ingredient mixed with six-grain types fermented by B. coagulans, in reducing fat mass in adults with obesity.MethodsIn this randomized double-blinded placebo-controlled study, 100 participants [aged 40–65 years; body mass index (BMI) ≥ 25 to ≤ 33 kg/m2) were randomly allocated to two groups: 4 g/day Curezyme–LAC administered as a granulated powder or placebo (steamed grain powder mixture).ResultsAfter 12 weeks, visceral adipose tissue decreased significantly in the Curezyme–LAC group compared with that in the placebo group (mean ± standard error, SE of −9.3 cm2 ± 5.1) vs. (6.8 cm2 ± 3.4; p = 0.008). Compared to the placebo group, the Curezyme–LAC group also showed significant reductions in total fat mass (−0.43 ± 0.24 kg vs. 0.31 ± 0.19 kg, p = 0.011), body weight (−0.4 ± 0.3 kg vs. 0.3 ± 0.2 kg, p = 0.021), BMI (−0.14 ± 0.12 vs. 0.10 ± 0.07, p = 0.028), and waist circumference (−0.6 ± 0.2 cm vs. −0.1 ± 0.2 cm, p = 0.018) without a change in dietary intake and physical activity.ConclusionCurezyme–LAC supplementation for 12 weeks may benefit individuals with obesity by reducing visceral fat mass. |
| first_indexed | 2024-04-09T17:41:01Z |
| format | Article |
| id | doaj.art-be44109068384c8bba28301a0f21cfe3 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-09T17:41:01Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-be44109068384c8bba28301a0f21cfe32023-04-17T05:51:38ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-04-011010.3389/fnut.2023.11485121148512Efficacy of fermented grain using Bacillus coagulans in reducing visceral fat among people with obesity: a randomized controlled trialEunbyul Cho0Ju Young Kim1Belong Cho2Joong Su Lee3Yeo Cho Yoon4Yong Chul Shin5Hyerim Kim6Siye Gil7Sohye Kim8Department of Family Medicine, Seoul National University Bundang Hospital, Seongnam-si, Republic of KoreaDepartment of Family Medicine, Seoul National University Bundang Hospital, Seongnam-si, Republic of KoreaDepartment of Family Medicine, Seoul National University College of Medicine, Seoul, Republic of KoreaAmicogen, Inc., Jinju-si, Republic of KoreaAmicogen, Inc., Jinju-si, Republic of KoreaAmicogen, Inc., Jinju-si, Republic of KoreaDepartment of Family Medicine, Seoul National University Bundang Hospital, Seongnam-si, Republic of KoreaDepartment of Family Medicine, Seoul National University Bundang Hospital, Seongnam-si, Republic of KoreaNutrition Care Services, Seoul National University Bundang Hospital, Seongnam-si, Republic of KoreaBackgroundObesity is a socioeconomic problem, and visceral obesity, in particular, is related to cardiovascular diseases or metabolic syndrome. Fermented grains and various microorganisms are known to help with anti-obesity effects and weight management. Studies on the relationship between Bacillus coagulans and anti-obesity effects are not well known, and studies on the application of fermented grains and microorganisms to the human body are also insufficient.ObjectivesThis study aimed to evaluate the efficacy of Curezyme–LAC, an ingredient mixed with six-grain types fermented by B. coagulans, in reducing fat mass in adults with obesity.MethodsIn this randomized double-blinded placebo-controlled study, 100 participants [aged 40–65 years; body mass index (BMI) ≥ 25 to ≤ 33 kg/m2) were randomly allocated to two groups: 4 g/day Curezyme–LAC administered as a granulated powder or placebo (steamed grain powder mixture).ResultsAfter 12 weeks, visceral adipose tissue decreased significantly in the Curezyme–LAC group compared with that in the placebo group (mean ± standard error, SE of −9.3 cm2 ± 5.1) vs. (6.8 cm2 ± 3.4; p = 0.008). Compared to the placebo group, the Curezyme–LAC group also showed significant reductions in total fat mass (−0.43 ± 0.24 kg vs. 0.31 ± 0.19 kg, p = 0.011), body weight (−0.4 ± 0.3 kg vs. 0.3 ± 0.2 kg, p = 0.021), BMI (−0.14 ± 0.12 vs. 0.10 ± 0.07, p = 0.028), and waist circumference (−0.6 ± 0.2 cm vs. −0.1 ± 0.2 cm, p = 0.018) without a change in dietary intake and physical activity.ConclusionCurezyme–LAC supplementation for 12 weeks may benefit individuals with obesity by reducing visceral fat mass.https://www.frontiersin.org/articles/10.3389/fnut.2023.1148512/fullvisceral fatanti-obesityfermented grainBacillus coagulansweight management |
| spellingShingle | Eunbyul Cho Ju Young Kim Belong Cho Joong Su Lee Yeo Cho Yoon Yong Chul Shin Hyerim Kim Siye Gil Sohye Kim Efficacy of fermented grain using Bacillus coagulans in reducing visceral fat among people with obesity: a randomized controlled trial Frontiers in Nutrition visceral fat anti-obesity fermented grain Bacillus coagulans weight management |
| title | Efficacy of fermented grain using Bacillus coagulans in reducing visceral fat among people with obesity: a randomized controlled trial |
| title_full | Efficacy of fermented grain using Bacillus coagulans in reducing visceral fat among people with obesity: a randomized controlled trial |
| title_fullStr | Efficacy of fermented grain using Bacillus coagulans in reducing visceral fat among people with obesity: a randomized controlled trial |
| title_full_unstemmed | Efficacy of fermented grain using Bacillus coagulans in reducing visceral fat among people with obesity: a randomized controlled trial |
| title_short | Efficacy of fermented grain using Bacillus coagulans in reducing visceral fat among people with obesity: a randomized controlled trial |
| title_sort | efficacy of fermented grain using bacillus coagulans in reducing visceral fat among people with obesity a randomized controlled trial |
| topic | visceral fat anti-obesity fermented grain Bacillus coagulans weight management |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1148512/full |
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