Neuroendocrine Tumors: Clinical, Histological and Immunohistochemical Perspectives and Case Report—Mature Teratoma in a 16-Year-Old Girl
A mature teratoma is a germinal neoplasm that differentiates from embryonic multipotent cells into three germ layers. There may also be glandular tissue. The literature describes a total of 658 cases of ovarian neuroendocrine neoplasms, mainly in women over 40 years of age. The authors, together wit...
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MDPI AG
2021-08-01
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| Series: | Pathophysiology |
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| author | Elżbieta Sowińska-Przepiera Dariusz Starzyński Anhelli Syrenicz Ireneusz Dziuba Barbara Wiszniewska Sylwia Rzeszotek |
| author_facet | Elżbieta Sowińska-Przepiera Dariusz Starzyński Anhelli Syrenicz Ireneusz Dziuba Barbara Wiszniewska Sylwia Rzeszotek |
| author_sort | Elżbieta Sowińska-Przepiera |
| collection | DOAJ |
| description | A mature teratoma is a germinal neoplasm that differentiates from embryonic multipotent cells into three germ layers. There may also be glandular tissue. The literature describes a total of 658 cases of ovarian neuroendocrine neoplasms, mainly in women over 40 years of age. The authors, together with a systemic review, present a case of a 16-year-old girl diagnosed with and treated for a neuroendocrine tumor. Case description: A 16-year-old girl visited the Paediatric Gynaecology Outpatient Clinic because of abdominal pains that intensified during menstruation. Standard painkillers and diastolic drugs were ineffective. An ultrasound examination revealed a large tumor with a heterogeneous structure in her right ovary. A sparing operation was carried out. During laparotomy, the lesion was enucleated, leaving healthy tissue. Histopathological examination revealed the typical features of teratoma, as well as the coexistence of a G1 neuroendocrine tumor. Immunohistochemical examination (IHC) showed the presence of markers characteristic for this type of tumor. The patient requires constant monitoring in the Endocrinology and Oncological Gynaecology Clinic. Conclusion: Tissue of neuroendocrine neoplasm within a teratoma is rare in this age group of patients; thus, there are currently no standards for long-term follow-up. This case adds to the body of evidence and demonstrates a possible good prognosis with non-aggressive behavior in G1 neuroendocrine tumors and teratomas in young patients. |
| first_indexed | 2024-03-10T07:19:34Z |
| format | Article |
| id | doaj.art-be444640c2634a15b645701c80adf6ff |
| institution | Directory Open Access Journal |
| issn | 1873-149X |
| language | English |
| last_indexed | 2024-03-10T07:19:34Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathophysiology |
| spelling | doaj.art-be444640c2634a15b645701c80adf6ff2023-11-22T14:43:39ZengMDPI AGPathophysiology1873-149X2021-08-0128337338610.3390/pathophysiology28030025Neuroendocrine Tumors: Clinical, Histological and Immunohistochemical Perspectives and Case Report—Mature Teratoma in a 16-Year-Old GirlElżbieta Sowińska-Przepiera0Dariusz Starzyński1Anhelli Syrenicz2Ireneusz Dziuba3Barbara Wiszniewska4Sylwia Rzeszotek5Department of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University (PMU), 71-252 Szczecin, PolandDepartment of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University (PMU), 71-252 Szczecin, PolandDepartment of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University (PMU), 71-252 Szczecin, PolandFaculty of Medicine, University of Technology, 40-555 Katowice, PolandDepartment of Histology and Embryology, Pomeranian Medical University (PMU), 70-111 Szczecin, PolandDepartment of Histology and Embryology, Pomeranian Medical University (PMU), 70-111 Szczecin, PolandA mature teratoma is a germinal neoplasm that differentiates from embryonic multipotent cells into three germ layers. There may also be glandular tissue. The literature describes a total of 658 cases of ovarian neuroendocrine neoplasms, mainly in women over 40 years of age. The authors, together with a systemic review, present a case of a 16-year-old girl diagnosed with and treated for a neuroendocrine tumor. Case description: A 16-year-old girl visited the Paediatric Gynaecology Outpatient Clinic because of abdominal pains that intensified during menstruation. Standard painkillers and diastolic drugs were ineffective. An ultrasound examination revealed a large tumor with a heterogeneous structure in her right ovary. A sparing operation was carried out. During laparotomy, the lesion was enucleated, leaving healthy tissue. Histopathological examination revealed the typical features of teratoma, as well as the coexistence of a G1 neuroendocrine tumor. Immunohistochemical examination (IHC) showed the presence of markers characteristic for this type of tumor. The patient requires constant monitoring in the Endocrinology and Oncological Gynaecology Clinic. Conclusion: Tissue of neuroendocrine neoplasm within a teratoma is rare in this age group of patients; thus, there are currently no standards for long-term follow-up. This case adds to the body of evidence and demonstrates a possible good prognosis with non-aggressive behavior in G1 neuroendocrine tumors and teratomas in young patients.https://www.mdpi.com/1873-149X/28/3/25germinal neoplasmneuroendocrine tumorovarian tumorpediatric gynecologyteratomaIHC |
| spellingShingle | Elżbieta Sowińska-Przepiera Dariusz Starzyński Anhelli Syrenicz Ireneusz Dziuba Barbara Wiszniewska Sylwia Rzeszotek Neuroendocrine Tumors: Clinical, Histological and Immunohistochemical Perspectives and Case Report—Mature Teratoma in a 16-Year-Old Girl Pathophysiology germinal neoplasm neuroendocrine tumor ovarian tumor pediatric gynecology teratoma IHC |
| title | Neuroendocrine Tumors: Clinical, Histological and Immunohistochemical Perspectives and Case Report—Mature Teratoma in a 16-Year-Old Girl |
| title_full | Neuroendocrine Tumors: Clinical, Histological and Immunohistochemical Perspectives and Case Report—Mature Teratoma in a 16-Year-Old Girl |
| title_fullStr | Neuroendocrine Tumors: Clinical, Histological and Immunohistochemical Perspectives and Case Report—Mature Teratoma in a 16-Year-Old Girl |
| title_full_unstemmed | Neuroendocrine Tumors: Clinical, Histological and Immunohistochemical Perspectives and Case Report—Mature Teratoma in a 16-Year-Old Girl |
| title_short | Neuroendocrine Tumors: Clinical, Histological and Immunohistochemical Perspectives and Case Report—Mature Teratoma in a 16-Year-Old Girl |
| title_sort | neuroendocrine tumors clinical histological and immunohistochemical perspectives and case report mature teratoma in a 16 year old girl |
| topic | germinal neoplasm neuroendocrine tumor ovarian tumor pediatric gynecology teratoma IHC |
| url | https://www.mdpi.com/1873-149X/28/3/25 |
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