Determinants of cancer incidence and mortality among people with vitamin D deficiency: an epidemiology study using a real-world population database
IntroductionThis study aimed to investigate the determinants of cancer incidence and mortality in patients with vitamin D deficiency using a real-world population database.MethodsWe utilized the International Diagnostic Classification Code (ICD9:268 / ICD10: E55) to define patients with vitamin D de...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1294066/full |
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| author | Yi-Chen Lai Yu-Han Chen Fu-Wen Liang Fu-Wen Liang Fu-Wen Liang Yu-Cih Wu Jhi-Joung Wang Jhi-Joung Wang Sher-Wei Lim Sher-Wei Lim Chung-Han Ho Chung-Han Ho Chung-Han Ho |
| author_facet | Yi-Chen Lai Yu-Han Chen Fu-Wen Liang Fu-Wen Liang Fu-Wen Liang Yu-Cih Wu Jhi-Joung Wang Jhi-Joung Wang Sher-Wei Lim Sher-Wei Lim Chung-Han Ho Chung-Han Ho Chung-Han Ho |
| author_sort | Yi-Chen Lai |
| collection | DOAJ |
| description | IntroductionThis study aimed to investigate the determinants of cancer incidence and mortality in patients with vitamin D deficiency using a real-world population database.MethodsWe utilized the International Diagnostic Classification Code (ICD9:268 / ICD10: E55) to define patients with vitamin D deficiency. Additionally, the Cox regression model was used to estimate overall mortality and identify potential factors contributing to mortality in cancer patients.ResultsIn 5242 patients with vitamin D deficiency, the development of new-onset cancer was 229 (4.37%) patients. Colon cancer was the most prevalent cancer type. After considering confounding factors, patients aged 50–65 and more than 65 indicated a 3.10-fold (95% C.I.: 2.12–4.51) and 4.55-fold (95% C.I.: 3.03–6.82) cancer incidence, respectively compared with those aged <50. Moreover, patients with comorbidities of diabetes mellitus (DM) (HR: 1.56; 95% C.I.: 1.01–2.41) and liver disease (HR: 1.62; 95% C.I.: 1.03–2.54) presented a higher cancer incidence rate than those without DM/ liver disease. In addition, vitamin D deficiency patients with cancer and dementia histories indicated a significantly higher mortality risk (HR: 4.04; 95% C.I.: 1.05– 15.56) than those without dementia.ConclusionIn conclusion, our study revealed that vitamin D deficiency patients with liver disease had an increased incidence of cancer, while those with dementia had an increased mortality rate among cancer patients. |
| first_indexed | 2024-03-09T02:12:03Z |
| format | Article |
| id | doaj.art-be44febc84764de6bde29a6954359634 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-09T02:12:03Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-be44febc84764de6bde29a69543596342023-12-07T10:11:28ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-12-011010.3389/fnut.2023.12940661294066Determinants of cancer incidence and mortality among people with vitamin D deficiency: an epidemiology study using a real-world population databaseYi-Chen Lai0Yu-Han Chen1Fu-Wen Liang2Fu-Wen Liang3Fu-Wen Liang4Yu-Cih Wu5Jhi-Joung Wang6Jhi-Joung Wang7Sher-Wei Lim8Sher-Wei Lim9Chung-Han Ho10Chung-Han Ho11Chung-Han Ho12Department of Emergency Medicine, An Nan Hospital, China Medical University, Tainan, TaiwanDepartment of Family Medicine, An Nan Hospital, China Medical University, Tainan, TaiwanDepartment of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanCenter for Big Data Research, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Medical Research, Chi-Mei Medical Center, Tainan, TaiwanDepartment of Medical Research, Chi-Mei Medical Center, Tainan, TaiwanDepartment of Anesthesiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, TaiwanDepartment of Neurosurgery, Chi Mei Medical Center, Chiali, Tainan, TaiwanDepartment of Nursing, Min-Hwei College of Health Care Management, Tainan, TaiwanDepartment of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan0Department of Information Management, Southern Taiwan University of Science and Technology, Tainan, Taiwan1Cancer Center, Taipei Municipal Wanfang Hospital, Taipei Medical University, Taipei, TaiwanIntroductionThis study aimed to investigate the determinants of cancer incidence and mortality in patients with vitamin D deficiency using a real-world population database.MethodsWe utilized the International Diagnostic Classification Code (ICD9:268 / ICD10: E55) to define patients with vitamin D deficiency. Additionally, the Cox regression model was used to estimate overall mortality and identify potential factors contributing to mortality in cancer patients.ResultsIn 5242 patients with vitamin D deficiency, the development of new-onset cancer was 229 (4.37%) patients. Colon cancer was the most prevalent cancer type. After considering confounding factors, patients aged 50–65 and more than 65 indicated a 3.10-fold (95% C.I.: 2.12–4.51) and 4.55-fold (95% C.I.: 3.03–6.82) cancer incidence, respectively compared with those aged <50. Moreover, patients with comorbidities of diabetes mellitus (DM) (HR: 1.56; 95% C.I.: 1.01–2.41) and liver disease (HR: 1.62; 95% C.I.: 1.03–2.54) presented a higher cancer incidence rate than those without DM/ liver disease. In addition, vitamin D deficiency patients with cancer and dementia histories indicated a significantly higher mortality risk (HR: 4.04; 95% C.I.: 1.05– 15.56) than those without dementia.ConclusionIn conclusion, our study revealed that vitamin D deficiency patients with liver disease had an increased incidence of cancer, while those with dementia had an increased mortality rate among cancer patients.https://www.frontiersin.org/articles/10.3389/fnut.2023.1294066/fullvitamin D deficiencycancer incidencemortality riskTaiwan cancer registryreal-world data |
| spellingShingle | Yi-Chen Lai Yu-Han Chen Fu-Wen Liang Fu-Wen Liang Fu-Wen Liang Yu-Cih Wu Jhi-Joung Wang Jhi-Joung Wang Sher-Wei Lim Sher-Wei Lim Chung-Han Ho Chung-Han Ho Chung-Han Ho Determinants of cancer incidence and mortality among people with vitamin D deficiency: an epidemiology study using a real-world population database Frontiers in Nutrition vitamin D deficiency cancer incidence mortality risk Taiwan cancer registry real-world data |
| title | Determinants of cancer incidence and mortality among people with vitamin D deficiency: an epidemiology study using a real-world population database |
| title_full | Determinants of cancer incidence and mortality among people with vitamin D deficiency: an epidemiology study using a real-world population database |
| title_fullStr | Determinants of cancer incidence and mortality among people with vitamin D deficiency: an epidemiology study using a real-world population database |
| title_full_unstemmed | Determinants of cancer incidence and mortality among people with vitamin D deficiency: an epidemiology study using a real-world population database |
| title_short | Determinants of cancer incidence and mortality among people with vitamin D deficiency: an epidemiology study using a real-world population database |
| title_sort | determinants of cancer incidence and mortality among people with vitamin d deficiency an epidemiology study using a real world population database |
| topic | vitamin D deficiency cancer incidence mortality risk Taiwan cancer registry real-world data |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1294066/full |
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