Nano-Enabled Strategies for the Treatment of Lung Cancer: Potential Bottlenecks and Future Perspectives
On a global scale, lung cancer is acknowledged to be the major driver of cancer death attributable to treatment challenges and poor prognosis. Classical cancer treatment regimens, such as chemotherapy or radiotherapy, can be used to treat lung cancer, but the appended adverse effects limit them. Bec...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/2/473 |
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| author | Mohammed Kanan Alshammari Eman Yaser Almomen Kholoud Falah Alshahrani Shroog Farhan Altwalah Mehnaz Kamal May Faiz Al-Twallah Suheir Hassan Alsanad Mariam Hassan Al-Batti Faisal Jarallah Al-Rasheed Abdulaziz Yousef Alsalamah Mohammed Bader Alhazza Faisal Abdu Alasmari Abida Mohd Imran |
| author_facet | Mohammed Kanan Alshammari Eman Yaser Almomen Kholoud Falah Alshahrani Shroog Farhan Altwalah Mehnaz Kamal May Faiz Al-Twallah Suheir Hassan Alsanad Mariam Hassan Al-Batti Faisal Jarallah Al-Rasheed Abdulaziz Yousef Alsalamah Mohammed Bader Alhazza Faisal Abdu Alasmari Abida Mohd Imran |
| author_sort | Mohammed Kanan Alshammari |
| collection | DOAJ |
| description | On a global scale, lung cancer is acknowledged to be the major driver of cancer death attributable to treatment challenges and poor prognosis. Classical cancer treatment regimens, such as chemotherapy or radiotherapy, can be used to treat lung cancer, but the appended adverse effects limit them. Because of the numerous side effects associated with these treatment modalities, it is crucial to strive to develop novel and better strategies for managing lung cancer. Attributes such as enhanced bioavailability, better in vivo stability, intestinal absorption pattern, solubility, prolonged and targeted distribution, and the superior therapeutic effectiveness of numerous anticancer drugs have all been boosted with the emergence of nano-based therapeutic systems. Lipid-based polymeric and inorganic nano-formulations are now being explored for the targeted delivery of chemotherapeutics for lung cancer treatment. Nano-based approaches are pioneering the route for primary and metastatic lung cancer diagnosis and treatment. The implementation and development of innovative nanocarriers for drug administration, particularly for developing cancer therapies, is an intriguing and challenging task in the scientific domain. The current article provides an overview of the delivery methods, such as passive and active targeting for chemotherapeutics to treat lung cancer. Combinatorial drug therapy and techniques to overcome drug resistance in lung cancer cells, as potential ways to increase treatment effectiveness, are also discussed. In addition, the clinical studies of the potential therapies at different stages and the associated challenges are also presented. A summary of patent literature has also been included to keep readers aware of the new and innovative nanotechnology-based ways to treat lung cancer. |
| first_indexed | 2024-03-11T09:07:17Z |
| format | Article |
| id | doaj.art-be4705b430ae4ed1917c0c768db6b319 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T09:07:17Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-be4705b430ae4ed1917c0c768db6b3192023-11-16T19:18:45ZengMDPI AGBiomedicines2227-90592023-02-0111247310.3390/biomedicines11020473Nano-Enabled Strategies for the Treatment of Lung Cancer: Potential Bottlenecks and Future PerspectivesMohammed Kanan Alshammari0Eman Yaser Almomen1Kholoud Falah Alshahrani2Shroog Farhan Altwalah3Mehnaz Kamal4May Faiz Al-Twallah5Suheir Hassan Alsanad6Mariam Hassan Al-Batti7Faisal Jarallah Al-Rasheed8Abdulaziz Yousef Alsalamah9Mohammed Bader Alhazza10Faisal Abdu Alasmari11Abida12Mohd Imran13Department of Clinical Pharmacy, King Fahad Medical City, Riyadh 12211, Saudi ArabiaSaud Al-Babtain Cardiac Center, Nursing Quality, Dammam 32245, Saudi ArabiaCollege of Pharmacy, King Khalid University, Abha 62463, Saudi ArabiaCollege of Pharmacy, University of Hail, Hail 55424, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi ArabiaDepartment of Pharmaceutical Care, Northern Area Armed Forces Hospital, Hafar Albaten 10018, Saudi ArabiaDepartment of Pharmacy, Maternity and Children Hospital, Dammam 63430, Saudi ArabiaDepartment of Pharmacy, Maternity and Children Hospital, Dammam 63430, Saudi ArabiaPharmaceutical Care Department, Ministry of National Guard Health Affairs, Qassim 51911, Saudi ArabiaPharmaceutical Care Department, Ministry of Defense Health Services, Qassim 51911, Saudi ArabiaJohn Hopkins Armco Healthcare, Dhahran 34465, Saudi ArabiaInpatient Pharmacy Department, National Care Hospital, Riyadh 11541, Saudi ArabiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi ArabiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi ArabiaOn a global scale, lung cancer is acknowledged to be the major driver of cancer death attributable to treatment challenges and poor prognosis. Classical cancer treatment regimens, such as chemotherapy or radiotherapy, can be used to treat lung cancer, but the appended adverse effects limit them. Because of the numerous side effects associated with these treatment modalities, it is crucial to strive to develop novel and better strategies for managing lung cancer. Attributes such as enhanced bioavailability, better in vivo stability, intestinal absorption pattern, solubility, prolonged and targeted distribution, and the superior therapeutic effectiveness of numerous anticancer drugs have all been boosted with the emergence of nano-based therapeutic systems. Lipid-based polymeric and inorganic nano-formulations are now being explored for the targeted delivery of chemotherapeutics for lung cancer treatment. Nano-based approaches are pioneering the route for primary and metastatic lung cancer diagnosis and treatment. The implementation and development of innovative nanocarriers for drug administration, particularly for developing cancer therapies, is an intriguing and challenging task in the scientific domain. The current article provides an overview of the delivery methods, such as passive and active targeting for chemotherapeutics to treat lung cancer. Combinatorial drug therapy and techniques to overcome drug resistance in lung cancer cells, as potential ways to increase treatment effectiveness, are also discussed. In addition, the clinical studies of the potential therapies at different stages and the associated challenges are also presented. A summary of patent literature has also been included to keep readers aware of the new and innovative nanotechnology-based ways to treat lung cancer.https://www.mdpi.com/2227-9059/11/2/473nanotechnologylung cancerpassive targetingdrug resistanceactive targetingclinical studies |
| spellingShingle | Mohammed Kanan Alshammari Eman Yaser Almomen Kholoud Falah Alshahrani Shroog Farhan Altwalah Mehnaz Kamal May Faiz Al-Twallah Suheir Hassan Alsanad Mariam Hassan Al-Batti Faisal Jarallah Al-Rasheed Abdulaziz Yousef Alsalamah Mohammed Bader Alhazza Faisal Abdu Alasmari Abida Mohd Imran Nano-Enabled Strategies for the Treatment of Lung Cancer: Potential Bottlenecks and Future Perspectives Biomedicines nanotechnology lung cancer passive targeting drug resistance active targeting clinical studies |
| title | Nano-Enabled Strategies for the Treatment of Lung Cancer: Potential Bottlenecks and Future Perspectives |
| title_full | Nano-Enabled Strategies for the Treatment of Lung Cancer: Potential Bottlenecks and Future Perspectives |
| title_fullStr | Nano-Enabled Strategies for the Treatment of Lung Cancer: Potential Bottlenecks and Future Perspectives |
| title_full_unstemmed | Nano-Enabled Strategies for the Treatment of Lung Cancer: Potential Bottlenecks and Future Perspectives |
| title_short | Nano-Enabled Strategies for the Treatment of Lung Cancer: Potential Bottlenecks and Future Perspectives |
| title_sort | nano enabled strategies for the treatment of lung cancer potential bottlenecks and future perspectives |
| topic | nanotechnology lung cancer passive targeting drug resistance active targeting clinical studies |
| url | https://www.mdpi.com/2227-9059/11/2/473 |
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