The hope for an HIV vaccine based on induction of CD8+ T lymphocytes: a review
The only long-term and cost-effective solution to the human immunodeficiency virus (HIV) epidemic in the developing world is a vaccine that prevents individuals from becoming infected or, once infected, from passing the virus on to others. There is currently little hope for an AIDS vaccine. Conventi...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2008-03-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000200001 |
| _version_ | 1797757635645145088 |
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| author | David I Watkins |
| author_facet | David I Watkins |
| author_sort | David I Watkins |
| collection | DOAJ |
| description | The only long-term and cost-effective solution to the human immunodeficiency virus (HIV) epidemic in the developing world is a vaccine that prevents individuals from becoming infected or, once infected, from passing the virus on to others. There is currently little hope for an AIDS vaccine. Conventional attempts to induce protective antibody and CD8+ lymphocyte responses against HIV and simian immunodeficiency virus (SIV) have failed. The enormous diversity of the virus has only recently been appreciated by vaccinologists, and our assays to determine CD8+ lymphocyte antiviral efficacy are inadequate. The central hypothesis of a CTL-based vaccine is that particularly effective CD8+ lymphocytes directed against at least five epitopes that are derived from regions under functional and structural constraints will control replication of pathogenic SIV. This would be somewhat analogous to control of virus replication by triple drug therapy or neutralizing antibodies. |
| first_indexed | 2024-03-12T18:18:30Z |
| format | Article |
| id | doaj.art-be486885eb4e4f34a7c4e782de616cca |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:18:30Z |
| publishDate | 2008-03-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-be486885eb4e4f34a7c4e782de616cca2023-08-02T09:00:10ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602008-03-01103211912910.1590/S0074-02762008000200001The hope for an HIV vaccine based on induction of CD8+ T lymphocytes: a reviewDavid I WatkinsThe only long-term and cost-effective solution to the human immunodeficiency virus (HIV) epidemic in the developing world is a vaccine that prevents individuals from becoming infected or, once infected, from passing the virus on to others. There is currently little hope for an AIDS vaccine. Conventional attempts to induce protective antibody and CD8+ lymphocyte responses against HIV and simian immunodeficiency virus (SIV) have failed. The enormous diversity of the virus has only recently been appreciated by vaccinologists, and our assays to determine CD8+ lymphocyte antiviral efficacy are inadequate. The central hypothesis of a CTL-based vaccine is that particularly effective CD8+ lymphocytes directed against at least five epitopes that are derived from regions under functional and structural constraints will control replication of pathogenic SIV. This would be somewhat analogous to control of virus replication by triple drug therapy or neutralizing antibodies.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000200001CTLHIVSIVVaccines |
| spellingShingle | David I Watkins The hope for an HIV vaccine based on induction of CD8+ T lymphocytes: a review Memorias do Instituto Oswaldo Cruz CTL HIV SIV Vaccines |
| title | The hope for an HIV vaccine based on induction of CD8+ T lymphocytes: a review |
| title_full | The hope for an HIV vaccine based on induction of CD8+ T lymphocytes: a review |
| title_fullStr | The hope for an HIV vaccine based on induction of CD8+ T lymphocytes: a review |
| title_full_unstemmed | The hope for an HIV vaccine based on induction of CD8+ T lymphocytes: a review |
| title_short | The hope for an HIV vaccine based on induction of CD8+ T lymphocytes: a review |
| title_sort | hope for an hiv vaccine based on induction of cd8 t lymphocytes a review |
| topic | CTL HIV SIV Vaccines |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000200001 |
| work_keys_str_mv | AT davidiwatkins thehopeforanhivvaccinebasedoninductionofcd8tlymphocytesareview AT davidiwatkins hopeforanhivvaccinebasedoninductionofcd8tlymphocytesareview |