Dihydroxyquingdainone Induces Apoptosis in Leukaemia and Lymphoma Cells via the Mitochondrial Pathway in a Bcl-2- and Caspase-3-Dependent Manner and Overcomes Resistance to Cytostatic Drugs In Vitro

Dihydroxyquingdainone Induces Apoptosis in Leukaemia and Lymphoma Cells via the Mitochondrial Pathway in a Bcl-2- and Caspase-3-Dependent Manner and Overcomes Resistance to Cytostatic Drugs In Vitro

<i>Isatis tinctoria</i> and its indigo dyes have already provided highly active anti-leukaemic lead compounds, with the focus mainly being on indirubin, whereas indigo itself is inactive. There are many more indigoids to find in this plant extract, for example, quingdainone, an indigoid...

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Bibliographic Details
Main Authors: Jennifer Baas, Sebastian Bieringer, Corazon Frias, Jerico Frias, Carolina Soehnchen, Corinna Urmann, Steffi Ritter, Herbert Riepl, Aram Prokop
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Molecules
Subjects:
<i>Isatis tinctoria</i>
quingdainone
tryptanthrin
Nalm-6
BJAB
intrinsic apoptosis pathway
Online Access:https://www.mdpi.com/1420-3049/27/15/5038

Internet

https://www.mdpi.com/1420-3049/27/15/5038

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