Assessing the Evidence for Causal Associations Between Body Mass Index, C-Reactive Protein, Depression, and Reported Trauma Using Mendelian Randomization

Assessing the Evidence for Causal Associations Between Body Mass Index, C-Reactive Protein, Depression, and Reported Trauma Using Mendelian Randomization

Background: Traumatic experiences are described as the strongest predictors of major depressive disorder (MDD), with inflammation potentially mediating the association between trauma and symptom onset. However, several studies indicate that body mass index (BMI) exerts a large confounding effect on...

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Bibliographic Details
Main Authors: Alish B. Palmos, Christopher Hübel, Kai Xiang Lim, Avina K. Hunjan, Jonathan R.I. Coleman, Gerome Breen
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Biological Psychiatry Global Open Science
Subjects:
Body mass index
Causation
Depression
Genetics
Inflammation
Mendelian randomization
Online Access:http://www.sciencedirect.com/science/article/pii/S2667174322000088

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