Therapeutic Potential of a Senolytic Approach in a Murine Model of Chronic GVHD

Therapeutic Potential of a Senolytic Approach in a Murine Model of Chronic GVHD

Graft-versus-host disease (GVHD) is a life-threatening systemic complication of allogeneic hematopoietic stem cell transplantation (HSCT) characterized by dysregulation of T and B cell activation and function, scleroderma-like features, and multi-organ pathology. The treatment of cGVHD is limited to...

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Bibliographic Details
Main Authors: Deepika Raman, Charlotte Chêne, Carole Nicco, Mohamed Jeljeli, Jie Qing Eu, Marie-Véronique Clément, Frédéric Batteux, Shazib Pervaiz
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Biology
Subjects:
graft vs. host disease
quercetin
dasatinib
senescence
Online Access:https://www.mdpi.com/2079-7737/12/5/647

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