Highly potent multivalent VHH antibodies against Chikungunya isolated from an alpaca naïve phage display library

Highly potent multivalent VHH antibodies against Chikungunya isolated from an alpaca naïve phage display library

Abstract Background Chikungunya virus (CHIKV) is a re-emerged mosquito-borne alphavirus that can cause musculoskeletal diseases, imposing a substantial threat to public health globally. High-affinity antibodies are need for diagnosis and treatment of CHIKV infections. As a potential diagnostic and t...

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Bibliographic Details
Main Authors: Qianlin Li, Fuqiang Zhang, Yi Lu, Huan Hu, Jin Wang, Cheng Guo, Qiang Deng, Conghui Liao, Qin Wu, Tingsong Hu, Zeliang Chen, Jiahai Lu
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Nanobiotechnology
Subjects:
Chikungunya
VHH antibody
Naïve phage display library
E2 glycoprotein
Epitope
Online Access:https://doi.org/10.1186/s12951-022-01417-6

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