DOT1L Mediated Gene Repression in Extensively Self-Renewing Erythroblasts

DOT1L Mediated Gene Repression in Extensively Self-Renewing Erythroblasts

DOT1L is essential for embryonic hematopoiesis but the precise mechanisms of its action remain unclear. The only recognized function of DOT1L is histone H3 lysine 79 (H3K79) methylation, which has been implicated in both transcriptional activation and repression. We observed that deletion of the mou...

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Bibliographic Details
Main Authors:	Shaon Borosha, Anamika Ratri, Subhra Ghosh, Carrie A. Malcom, V. Praveen Chakravarthi, Jay L. Vivian, Timothy A. Fields, M. A. Karim Rumi, Patrick E. Fields
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-03-01
Series:	Frontiers in Genetics
Subjects:	DOT1L methyltransferase Dot1l methyltransferase mutant mouse erythroid-myeloid progenitors erythroid-myeloid differentiation mutant mouse models
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2022.828086/full

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