The role of matrix metalloproteinase-9 in the genesis of chronic bronchi inflammation in children with bronchial asthma
Bronchial asthma as the most common respiratory tract disease is an urgent problem of modern medicine. Matrix metalloproteinases (MMР) play a significant role in the processes of inflammation maintaining and bronchi remodeling in children with bronchial asthma.Objective: To study the role and inheri...
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| Format: | Article |
| Language: | Russian |
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Ltd. “The National Academy of Pediatric Science and Innovation”
2020-05-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/1107 |
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| author | A. A. Lebedenko O. E. Semernik M. V. Dudareva E. B. Tyurina |
| author_facet | A. A. Lebedenko O. E. Semernik M. V. Dudareva E. B. Tyurina |
| author_sort | A. A. Lebedenko |
| collection | DOAJ |
| description | Bronchial asthma as the most common respiratory tract disease is an urgent problem of modern medicine. Matrix metalloproteinases (MMР) play a significant role in the processes of inflammation maintaining and bronchi remodeling in children with bronchial asthma.Objective: To study the role and inheritance of MMR9 in the bronchial asthma pathogenesis in children.Characteristics of children and research methods. The authors carried out the prospective study of 54 children with bronchial asthma and 56 healthy children with the determination of the MMP-9 level in blood serum, as well as the polymorphic variant 8202A>G of MMP9 gene.Results. Children with bronchial asthma had significantly higher content of MMP9 in the blood serum (431.76 [306.15; 612.93] ng/ml), as compared to the control group (276.05 [160.33; 397.02] ng/ml). When studying polymorphism 8202A>G of MMP9 gene in the examined patients it was found that the children with bronchial asthma had the G allele a little more often (57.5%) than A allele (42.5%). Heterozygous carriers of the MMP9 gene polymorphic variant predominate both among the patients with bronchial asthma and in the control group. When comparing the frequency of genotypes and alleles in the group of children with bronchial asthma and control group the authors revealed no statistically significant differences.Conclusion. The disease mechanism significantly depends upon the MMR9 concentration in the serum of patients with bronchial asthma and the peculiarities of this enzyme inheritance. |
| first_indexed | 2024-04-10T01:42:43Z |
| format | Article |
| id | doaj.art-be502087210644bc8d247b8b8dfa62db |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:42:43Z |
| publishDate | 2020-05-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-be502087210644bc8d247b8b8dfa62db2023-03-13T09:12:48ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282020-05-01652495410.21508/1027-4065-2020-65-2-49-54866The role of matrix metalloproteinase-9 in the genesis of chronic bronchi inflammation in children with bronchial asthmaA. A. Lebedenko0O. E. Semernik1M. V. Dudareva2E. B. Tyurina3ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава РоссииBronchial asthma as the most common respiratory tract disease is an urgent problem of modern medicine. Matrix metalloproteinases (MMР) play a significant role in the processes of inflammation maintaining and bronchi remodeling in children with bronchial asthma.Objective: To study the role and inheritance of MMR9 in the bronchial asthma pathogenesis in children.Characteristics of children and research methods. The authors carried out the prospective study of 54 children with bronchial asthma and 56 healthy children with the determination of the MMP-9 level in blood serum, as well as the polymorphic variant 8202A>G of MMP9 gene.Results. Children with bronchial asthma had significantly higher content of MMP9 in the blood serum (431.76 [306.15; 612.93] ng/ml), as compared to the control group (276.05 [160.33; 397.02] ng/ml). When studying polymorphism 8202A>G of MMP9 gene in the examined patients it was found that the children with bronchial asthma had the G allele a little more often (57.5%) than A allele (42.5%). Heterozygous carriers of the MMP9 gene polymorphic variant predominate both among the patients with bronchial asthma and in the control group. When comparing the frequency of genotypes and alleles in the group of children with bronchial asthma and control group the authors revealed no statistically significant differences.Conclusion. The disease mechanism significantly depends upon the MMR9 concentration in the serum of patients with bronchial asthma and the peculiarities of this enzyme inheritance.https://www.ped-perinatology.ru/jour/article/view/1107дети, бронхиальная астма, металлопротеиназы, воспаление, генотип, ген mmp9 |
| spellingShingle | A. A. Lebedenko O. E. Semernik M. V. Dudareva E. B. Tyurina The role of matrix metalloproteinase-9 in the genesis of chronic bronchi inflammation in children with bronchial asthma Rossijskij Vestnik Perinatologii i Pediatrii дети, бронхиальная астма, металлопротеиназы, воспаление, генотип, ген mmp9 |
| title | The role of matrix metalloproteinase-9 in the genesis of chronic bronchi inflammation in children with bronchial asthma |
| title_full | The role of matrix metalloproteinase-9 in the genesis of chronic bronchi inflammation in children with bronchial asthma |
| title_fullStr | The role of matrix metalloproteinase-9 in the genesis of chronic bronchi inflammation in children with bronchial asthma |
| title_full_unstemmed | The role of matrix metalloproteinase-9 in the genesis of chronic bronchi inflammation in children with bronchial asthma |
| title_short | The role of matrix metalloproteinase-9 in the genesis of chronic bronchi inflammation in children with bronchial asthma |
| title_sort | role of matrix metalloproteinase 9 in the genesis of chronic bronchi inflammation in children with bronchial asthma |
| topic | дети, бронхиальная астма, металлопротеиназы, воспаление, генотип, ген mmp9 |
| url | https://www.ped-perinatology.ru/jour/article/view/1107 |
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