Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare
A twenty-year-old female saddle horse was referred for evaluation of a seven month, non-healing erosive lesion of the right hind hoof with proliferation and bleeding of the underlying soft tissues. This lesion had been twice surgically treated as a canker but rapidly recurred. Histological examinati...
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| Format: | Article |
| Language: | English |
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Tripoli University
2017-06-01
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| Series: | Open Veterinary Journal |
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| Online Access: | http://www.openveterinaryjournal.com/OVJ-2017-02-026%20E.P.%20Spugnini%20et%20al.pdf |
| _version_ | 1819022336804782080 |
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| author | Enrico Pierluigi Spugnini Carlo Bolaffio Licia Scacco Alfonso Baldi |
| author_facet | Enrico Pierluigi Spugnini Carlo Bolaffio Licia Scacco Alfonso Baldi |
| author_sort | Enrico Pierluigi Spugnini |
| collection | DOAJ |
| description | A twenty-year-old female saddle horse was referred for evaluation of a seven month, non-healing erosive lesion of the right hind hoof with proliferation and bleeding of the underlying soft tissues. This lesion had been twice surgically treated as a canker but rapidly recurred. Histological examination of the second excision revealed a well-differentiated squamous cell carcinoma. At presentation, the horse was mildly depressed, lame and partially non-weight-bearing on the right hind leg, which exhibited a 10 x 10 cm erosive and proliferative lesion remodeling the hoof. After completing staging procedures, the lesion was approached with surgery and intraoperative electrochemotherapy (ECT) administration of bleomycin in isolated limb perfusion. A second session of surgery and ECT was performed one month later, followed by three additional monthly sessions of ECT. During periodic recheck, the mare showed continuous improvement. One year after presentation, the mare was in complete remission and her gait markedly improved. ECT was well-tolerated and resulted in improved local control of a tumor in a challenging anatomical district. |
| first_indexed | 2024-12-21T04:21:23Z |
| format | Article |
| id | doaj.art-be540f15d2c047b7820f502ecbe2a0f8 |
| institution | Directory Open Access Journal |
| issn | 2218-6050 2218-6050 |
| language | English |
| last_indexed | 2024-12-21T04:21:23Z |
| publishDate | 2017-06-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj.art-be540f15d2c047b7820f502ecbe2a0f82022-12-21T19:16:10ZengTripoli UniversityOpen Veterinary Journal2218-60502218-60502017-06-0172192196http://dx.doi.org/10.4314/ovj.v7i2.18Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mareEnrico Pierluigi Spugnini0Carlo Bolaffio1Licia Scacco2Alfonso Baldi3Biopulse S.r.l., Naples, Italy and Equivet Roma Hospital, Rome, ItalyEquivet Roma Hospital, Rome, ItalyEquivet Roma Hospital, Rome, ItalyBiopulse S.r.l., Naples, Italy and Department of Environmental, Biological and Pharmaceutical Sciences and Technologies Campania University “Luigi Vanvitelli”, Caserta, ItalyA twenty-year-old female saddle horse was referred for evaluation of a seven month, non-healing erosive lesion of the right hind hoof with proliferation and bleeding of the underlying soft tissues. This lesion had been twice surgically treated as a canker but rapidly recurred. Histological examination of the second excision revealed a well-differentiated squamous cell carcinoma. At presentation, the horse was mildly depressed, lame and partially non-weight-bearing on the right hind leg, which exhibited a 10 x 10 cm erosive and proliferative lesion remodeling the hoof. After completing staging procedures, the lesion was approached with surgery and intraoperative electrochemotherapy (ECT) administration of bleomycin in isolated limb perfusion. A second session of surgery and ECT was performed one month later, followed by three additional monthly sessions of ECT. During periodic recheck, the mare showed continuous improvement. One year after presentation, the mare was in complete remission and her gait markedly improved. ECT was well-tolerated and resulted in improved local control of a tumor in a challenging anatomical district.http://www.openveterinaryjournal.com/OVJ-2017-02-026%20E.P.%20Spugnini%20et%20al.pdfBleomycinElectrochemotherapyEquineHoofSquamous cell carcinoma |
| spellingShingle | Enrico Pierluigi Spugnini Carlo Bolaffio Licia Scacco Alfonso Baldi Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare Open Veterinary Journal Bleomycin Electrochemotherapy Equine Hoof Squamous cell carcinoma |
| title | Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare |
| title_full | Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare |
| title_fullStr | Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare |
| title_full_unstemmed | Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare |
| title_short | Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare |
| title_sort | isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare |
| topic | Bleomycin Electrochemotherapy Equine Hoof Squamous cell carcinoma |
| url | http://www.openveterinaryjournal.com/OVJ-2017-02-026%20E.P.%20Spugnini%20et%20al.pdf |
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