Wnt/beta-catenin signaling in vertebrate eye development
The vertebrate eye is a highly specialized sensory organ, which is derived from the anterior neural plate, head surface ectoderm, and neural crest-derived mesenchyme. The single central eye field, generated from the anterior neural plate, divides to give rise to the optic vesicle, which evaginates t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00138/full |
| _version_ | 1818983751606075392 |
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| author | Naoko Fujimura |
| author_facet | Naoko Fujimura |
| author_sort | Naoko Fujimura |
| collection | DOAJ |
| description | The vertebrate eye is a highly specialized sensory organ, which is derived from the anterior neural plate, head surface ectoderm, and neural crest-derived mesenchyme. The single central eye field, generated from the anterior neural plate, divides to give rise to the optic vesicle, which evaginates towards the head surface ectoderm. Subsequently, the surface ectoderm, in conjunction with the optic vesicle invaginates to form the lens vesicle and double-layered optic cup, respectively. This complex process is controlled by transcription factors and several intracellular and extracellular signaling pathways including WNT/beta-catenin signaling. This signaling pathway plays an essential role in multiple developmental processes and has a profound effect on cell proliferation and cell fate determination. During eye development, the activity of WNT/beta-catenin signaling is tightly controlled. Faulty regulation of WNT/beta-catenin signaling results in multiple ocular malformations due to defects in the process of cell fate determination and differentiation. This mini-review summarizes recent findings on the role of WNT/beta-catenin signaling in eye development. Whilst this mini-review focuses on loss-of-function and gain-of-function mutants of WNT/beta-catenin signaling components, it also highlights some important aspects of beta-catenin-independent WNT signaling in the eye development at later stages. |
| first_indexed | 2024-12-20T18:08:05Z |
| format | Article |
| id | doaj.art-be54c592e613401f81dff27ba6d86c4f |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-20T18:08:05Z |
| publishDate | 2016-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-be54c592e613401f81dff27ba6d86c4f2022-12-21T19:30:33ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2016-11-01410.3389/fcell.2016.00138221674Wnt/beta-catenin signaling in vertebrate eye developmentNaoko Fujimura0Institute of Molecular Genetics, Academy of Sciences of the Czech RepublicThe vertebrate eye is a highly specialized sensory organ, which is derived from the anterior neural plate, head surface ectoderm, and neural crest-derived mesenchyme. The single central eye field, generated from the anterior neural plate, divides to give rise to the optic vesicle, which evaginates towards the head surface ectoderm. Subsequently, the surface ectoderm, in conjunction with the optic vesicle invaginates to form the lens vesicle and double-layered optic cup, respectively. This complex process is controlled by transcription factors and several intracellular and extracellular signaling pathways including WNT/beta-catenin signaling. This signaling pathway plays an essential role in multiple developmental processes and has a profound effect on cell proliferation and cell fate determination. During eye development, the activity of WNT/beta-catenin signaling is tightly controlled. Faulty regulation of WNT/beta-catenin signaling results in multiple ocular malformations due to defects in the process of cell fate determination and differentiation. This mini-review summarizes recent findings on the role of WNT/beta-catenin signaling in eye development. Whilst this mini-review focuses on loss-of-function and gain-of-function mutants of WNT/beta-catenin signaling components, it also highlights some important aspects of beta-catenin-independent WNT signaling in the eye development at later stages.http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00138/fullRetinadevelopmentWntdifferentiationbeta-Catenin |
| spellingShingle | Naoko Fujimura Wnt/beta-catenin signaling in vertebrate eye development Frontiers in Cell and Developmental Biology Retina development Wnt differentiation beta-Catenin |
| title | Wnt/beta-catenin signaling in vertebrate eye development |
| title_full | Wnt/beta-catenin signaling in vertebrate eye development |
| title_fullStr | Wnt/beta-catenin signaling in vertebrate eye development |
| title_full_unstemmed | Wnt/beta-catenin signaling in vertebrate eye development |
| title_short | Wnt/beta-catenin signaling in vertebrate eye development |
| title_sort | wnt beta catenin signaling in vertebrate eye development |
| topic | Retina development Wnt differentiation beta-Catenin |
| url | http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00138/full |
| work_keys_str_mv | AT naokofujimura wntbetacateninsignalinginvertebrateeyedevelopment |